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PRKAA1: protein kinase AMP-activated catalytic subunit alpha 1

1 protein, 20 patents, 1 drug, 2 trials, 7,031 NIH grants and 19,142 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRKAA1HGNC
Nameprotein kinase AMP-activated catalytic subunit alpha 1HGNC
NCBI Gene ID5562NCBI Gene
HGNC IDHGNC:9376HGNC
EnsemblENSG00000132356NCBI Gene
AliasesAMPK, AMPK alpha 1, AMPKa1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q131315'-AMP-activated protein kinase catalytic subunit alpha-155912Ensembl, GeneID, HGNCUniProt

Patents 20

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459754Q13131Espacenet
US 11884978 B22024-01-30679Q13131Espacenet
US 11446398 B22022-09-2068288Q13131Espacenet
JP 2022524081 A2022-04-27171259Q13131Espacenet
US 11273161 B22022-03-1517Q13131Espacenet
US 11078247 B22021-08-038924Q13131Espacenet
JP 2021018154 A2021-02-151110Q13131Espacenet
EP 3504344 A12019-07-03868Q13131Espacenet
JP 2019054813 A2019-04-11240189Q13131Espacenet
US 9999620 B22018-06-1922Q13131Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACADESINECHEMBL1551724AMP-activated protein kinase, AMPK activatorACTIVATORChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01813838ACADESINEPHASE1/PHASE2ClinicalTrials.gov
NCT00559624ACADESINEPHASE1/PHASE2ClinicalTrials.gov

NIH grants 7031

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1002,025NIH's project files
P30CA008748Cancer Center Support Grant402,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes342,025NIH's project files
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer222,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)212,025NIH's project files
ZIABC011043Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene212,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)202,025NIH's project files
ZIDBC011089Clinical Nursing and Data Management Core182,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant172,025NIH's project files
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene162,025NIH's project files

Papers 19142

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825909PubTator, text miningPubMed
42817135PubTator, text miningPubMed
42817107PubTator, text miningPubMed
42817098PubTator, text miningPubMed
42815263PubTator, text miningPubMed
42812993PubTator, text miningPubMed
42812057PubTator, text miningPubMed
42812051PubTator, text miningPubMed
42810623PubTator, text miningPubMed
42810055PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license