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PRKAA2: protein kinase AMP-activated catalytic subunit alpha 2

1 protein, 35 patents, 1 drug, 2 trials, 8,141 NIH grants and 22,848 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRKAA2HGNC
Nameprotein kinase AMP-activated catalytic subunit alpha 2HGNC
NCBI Gene ID5563NCBI Gene
HGNC IDHGNC:9377HGNC
EnsemblENSG00000162409NCBI Gene
AliasesAMPK, AMPK2, AMPKa2, PRKAANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P546465'-AMP-activated protein kinase catalytic subunit alpha-255215Ensembl, GeneID, HGNCUniProt

Patents 35

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459755P54646Espacenet
EP 4641201 A22025-10-299168P54646Espacenet
JP 2025147176 A2025-10-0616574P54646Espacenet
JP 2025529142 A2025-09-043575P54646Espacenet
US 12371689 B22025-07-293575P54646Espacenet
JP 2025517969 A2025-06-129168P54646Espacenet
JP 2025028160 A2025-02-2816574P54646Espacenet
KR 1020250010750 A2025-01-2116574P54646Espacenet
JP 2024109657 A2024-08-1416413P54646Espacenet
US 11446398 B22022-09-2068289P54646Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACADESINECHEMBL1551724AMP-activated protein kinase, AMPK activatorACTIVATORChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01813838ACADESINEPHASE1/PHASE2ClinicalTrials.gov
NCT00559624ACADESINEPHASE1/PHASE2ClinicalTrials.gov

NIH grants 8141

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1022,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes522,025NIH's project files
P30CA008748Cancer Center Support Grant332,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)332,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)282,025NIH's project files
P30DK036836Diabetes Research Center212,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program192,025NIH's project files
P30DK020579Diabetes Research Center192,025NIH's project files
P30DK072476Pennington/Louisiana NORC182,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award182,025NIH's project files

Papers 22848

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826791PubTator, text miningPubMed
42824365PubTator, text miningPubMed
42822442PubTator, text miningPubMed
42815861PubTator, text miningPubMed
42811267PubTator, text miningPubMed
42810013PubTator, text miningPubMed
42807071PubTator, text miningPubMed
42805187PubTator, text miningPubMed
42801528PubTator, text miningPubMed
42797459PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license