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PRKAB1: protein kinase AMP-activated non-catalytic subunit beta 1

1 protein, 45 patents, 1 drug, 2 trials, 6,459 NIH grants and 16,528 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRKAB1HGNC
Nameprotein kinase AMP-activated non-catalytic subunit beta 1HGNC
NCBI Gene ID5564NCBI Gene
HGNC IDHGNC:9378HGNC
EnsemblENSG00000111725NCBI Gene
AliasesAMPK, HAMPKbNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y4785'-AMP-activated protein kinase subunit beta-127012Ensembl, GeneID, HGNCUniProt

Patents 45

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19736Q9Y478Espacenet
JP 2025147176 A2025-10-0616575Q9Y478Espacenet
JP 2025517970 A2025-06-12736Q9Y478Espacenet
JP 2025028160 A2025-02-2816575Q9Y478Espacenet
KR 1020250010750 A2025-01-2116575Q9Y478Espacenet
JP 2024123008 A2024-09-107871Q9Y478Espacenet
JP 2024123008 A2024-09-107873Q9Y478Espacenet
JP 2024109657 A2024-08-1416414Q9Y478Espacenet
US 11446398 B22022-09-2068291Q9Y478Espacenet
US 11446398 B22022-09-2068294Q9Y478Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACADESINECHEMBL1551724AMP-activated protein kinase, AMPK activatorACTIVATORChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01813838ACADESINEPHASE1/PHASE2ClinicalTrials.gov
NCT00559624ACADESINEPHASE1/PHASE2ClinicalTrials.gov

NIH grants 6459

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant852,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes242,025NIH's project files
P30CA008748Cancer Center Support Grant212,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)192,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)162,025NIH's project files
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis142,025NIH's project files
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged142,025NIH's project files
U54GM104940Louisiana Clinical and Translational Science Center142,025NIH's project files
P40OD010440Caenorhabditis Genetics Center132,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center122,025NIH's project files

Papers 16528

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823400PubTator, text miningPubMed
42821047PubTator, text miningPubMed
42802722PubTator, text miningPubMed
42802420PubTator, text miningPubMed
42802280PubTator, text miningPubMed
42797077PubTator, text miningPubMed
42795030PubTator, text miningPubMed
42794785PubTator, text miningPubMed
42794733PubTator, text miningPubMed
42794563PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license