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Gene · 55669

MFN1: mitofusin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MFN1: mitofusin 1. Genes, record 55669. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55669

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Gene

Symbol
MFN1
HGNC
Name
mitofusin 1
HGNC
NCBI Gene ID
55669
NCBI Gene
HGNC ID
HGNC:18262
HGNC
Ensembl
ENSG00000171109
NCBI Gene
Aliases
FLJ20693, hfzo1, hfzo2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IWA4Mitofusin-17419Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192278Q8IWA4Espacenet
EP 4641201 A22025-10-291851Q8IWA4Espacenet
JP 2025529142 A2025-09-042608Q8IWA4Espacenet
US 12371689 B22025-07-292608Q8IWA4Espacenet
JP 2025517969 A2025-06-121851Q8IWA4Espacenet
JP 2025517970 A2025-06-122278Q8IWA4Espacenet
US 11834502 B22023-12-05109Q8IWA4Espacenet
US 11760733 B22023-09-195Q8IWA4Espacenet
US 11446398 B22022-09-2052339Q8IWA4Espacenet
US 11446398 B22022-09-2052344Q8IWA4Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,062

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMFN1 papersNewest fiscal year
ZIANS003123Role of mitochondria in neurodegenerative diseases162025
ZIANS002859Targeting Protein Aggregates for Autophagosomal Degradation112025
ZIANS003127Mechanisms of Autophagy112025
P30AG028740University of Florida Older Americans Independence Center (OAIC)82025
R35GM128915Molecular Principles Governing Mitochondrial and Peroxisomal Remodeling as Drivers of Cell Fate and Identity82025
P30CA010815Consolidated Basic Cancer Research Program62025
R01GM118509Determining the mechanism of mitochondrial outer membrane fusion62025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30CA013330Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 2,062Source NIH's project files

See all 2,062 nih grants

Papers3,795

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Periodontal ligament stem cells ameliorate experimental colitis by restoring macrophage mitochondrial homeostasis associated with PINK1/Parkin-related mitochondrial quality control.Biochim Biophys Acta Mol Basis Dis202742586510PubTator, text miningPubMed
Polydatin improves mitochondrial dynamics dysrhythmia by regulating BMAL1 to prevent and treat metabolic dysfunction-associated fatty liver disease.J Ethnopharmacol202742468884PubTator, text miningPubMed
Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder.Front Cell Neurosci202642787119PubTator, text miningPubMed
Recent advances in mitochondrial fission and fusion in diabetic cardiomyopathy.Front Cardiovasc Med202642761440PubTator, text miningPubMed
Reveal the diagnostic value of a neutrophil inflammation- and cell death-associated gene signature in rheumatoid arthritis.Medicine (Baltimore)202642760665PubTator, text miningPubMed
Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis.Cells202642738805PubTator, text miningPubMed
Effects of homozygous PARK7 gene mutations L166P and M26I on BNIP3/BNIP3L interactions and ER-mitochondria proximity.Biol Direct202642723107PubTator, text miningPubMed
Mitofusin 2 deficiency causes atrial lipid accumulation in experimental and human atrial fibrillation and diabetes mellitus.J Mol Cell Cardiol202642716427PubTator, text miningPubMed
MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair.Cell Rep202642678808PubTator, text miningPubMed
[Mechanical stimulation disrupts mitochondrial homeostasis and compromises biological functions of inflamed human periodontal ligament cells].Zhonghua Kou Qiang Yi Xue Za Zhi202642677438PubTator, text miningPubMed

1 to 10 of 3,795

See all 3,795 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/55669

GET https://conductscience.org/api/genes/v1/55669/patents