Gene · 55669
MFN1: mitofusin 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MFN1: mitofusin 1. Genes, record 55669. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55669
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8IWA4 | Mitofusin-1 | 741 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2278 | Q8IWA4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1851 | Q8IWA4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2608 | Q8IWA4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2608 | Q8IWA4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1851 | Q8IWA4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2278 | Q8IWA4 | Espacenet |
| US 11834502 B2 | 2023-12-05 | 109 | Q8IWA4 | Espacenet |
| US 11760733 B2 | 2023-09-19 | 5 | Q8IWA4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52339 | Q8IWA4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52344 | Q8IWA4 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,062
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MFN1 papers | Newest fiscal year |
|---|---|---|---|
| ZIANS003123 | Role of mitochondria in neurodegenerative diseases | 16 | 2025 |
| ZIANS002859 | Targeting Protein Aggregates for Autophagosomal Degradation | 11 | 2025 |
| ZIANS003127 | Mechanisms of Autophagy | 11 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 8 | 2025 |
| R35GM128915 | Molecular Principles Governing Mitochondrial and Peroxisomal Remodeling as Drivers of Cell Fate and Identity | 8 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 6 | 2025 |
| R01GM118509 | Determining the mechanism of mitochondrial outer membrane fusion | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 2,062Source NIH's project files
See all 2,062 nih grantsPapers3,795
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Periodontal ligament stem cells ameliorate experimental colitis by restoring macrophage mitochondrial homeostasis associated with PINK1/Parkin-related mitochondrial quality control. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42586510 | PubTator, text mining | PubMed |
| Polydatin improves mitochondrial dynamics dysrhythmia by regulating BMAL1 to prevent and treat metabolic dysfunction-associated fatty liver disease. | J Ethnopharmacol | 2027 | 42468884 | PubTator, text mining | PubMed |
| Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder. | Front Cell Neurosci | 2026 | 42787119 | PubTator, text mining | PubMed |
| Recent advances in mitochondrial fission and fusion in diabetic cardiomyopathy. | Front Cardiovasc Med | 2026 | 42761440 | PubTator, text mining | PubMed |
| Reveal the diagnostic value of a neutrophil inflammation- and cell death-associated gene signature in rheumatoid arthritis. | Medicine (Baltimore) | 2026 | 42760665 | PubTator, text mining | PubMed |
| Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis. | Cells | 2026 | 42738805 | PubTator, text mining | PubMed |
| Effects of homozygous PARK7 gene mutations L166P and M26I on BNIP3/BNIP3L interactions and ER-mitochondria proximity. | Biol Direct | 2026 | 42723107 | PubTator, text mining | PubMed |
| Mitofusin 2 deficiency causes atrial lipid accumulation in experimental and human atrial fibrillation and diabetes mellitus. | J Mol Cell Cardiol | 2026 | 42716427 | PubTator, text mining | PubMed |
| MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair. | Cell Rep | 2026 | 42678808 | PubTator, text mining | PubMed |
| [Mechanical stimulation disrupts mitochondrial homeostasis and compromises biological functions of inflamed human periodontal ligament cells]. | Zhonghua Kou Qiang Yi Xue Za Zhi | 2026 | 42677438 | PubTator, text mining | PubMed |
1 to 10 of 3,795
See all 3,795 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/55669
GET https://conductscience.org/api/genes/v1/55669/patents