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Gene · 5573

PRKAR1A: protein kinase cAMP-dependent type I regulatory subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRKAR1A: protein kinase cAMP-dependent type I regulatory subunit alpha. Genes, record 5573. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5573

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Gene

Symbol
PRKAR1A
HGNC
Name
protein kinase cAMP-dependent type I regulatory subunit alpha
HGNC
NCBI Gene ID
5573
NCBI Gene
HGNC ID
HGNC:9388
HGNC
Ensembl
ENSG00000108946
NCBI Gene
Aliases
ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, Prkar1alpha, TSE1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10644cAMP-dependent protein kinase type I-alpha regulatory subunit3813Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459736P10644Espacenet
JP 2026004568 A2026-01-1459786P10644Espacenet
JP 2026004568 A2026-01-1459787P10644Espacenet
JP 2026004568 A2026-01-1459788P10644Espacenet
JP 2026004568 A2026-01-1459789P10644Espacenet
EP 4650780 A22025-11-197569P10644Espacenet
JP 2025517970 A2025-06-127569P10644Espacenet
EP 4484957 A12025-01-0147P10644Espacenet
JP 2023552307 A2023-12-1541P10644Espacenet
WO 2023162878 A2023-08-3147P10644Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,475

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRKAR1A papersNewest fiscal year
P30CA008748Cancer Center Support Grant182025
P30CA016672Cancer Center Support Grant122025
P30CA016058Cancer Center Support Grant102025
R01DK062027Mechanisms of Adrenal Differentiation82025
ZIEHD008944Pediatric Endocrinology Training Program82025
R01GM117360Molecular Basis of mRNA Export72025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA047904Cancer Center Support Grant52025
P30CA006973Regional Oncology Research Center42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025

1 to 10 of 1,475Source NIH's project files

See all 1,475 nih grants

Papers2,806

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Rapid interval progression of familial atrial myxoma despite negative screening.Eur Heart J Case Rep202642813125PubTator, text miningPubMed
Familial acromegaly with a novel PRKAR1A splice-acceptor variant and marked intrafamilial phenotypic variability.JCEM Case Rep202642787346PubTator, text miningPubMed
[Clinical and genetic characteristics of 6 children with acrodysostosis].Zhonghua Er Ke Za Zhi202642742022PubTator, text miningPubMed
The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey.Fam Cancer202642667476PubTator, text miningPubMed
Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement.Nat Rev Endocrinol202642642458PubTator, text miningPubMed
Curcumin exerts distinct anti-tumor effects mediated by NRF1α from NRF2 via metabolic reprogramming in hepatocellular carcinoma (HepG2).Bioorg Chem202642623915PubTator, text miningPubMed
CHEK2 germline gene variant in a patient with a somatotrophinoma and primary hyperparathyroidism: a novel MEN1-like syndrome?Endocr Oncol202642582910PubTator, text miningPubMed
Integrated clinical-genetic-pathological analysis expands the phenotypic and molecular spectrum of PPNAD across carney complex and isolated forms.Eur J Endocrinol202642543523PubTator, text miningPubMed
Serum IgA autoantibody profiling in systemic lupus erythematosus reveals associations with disease phenotypes.RMD Open202642457208PubTator, text miningPubMed
PRKAR1A-related acrodysostosis with partial growth hormone deficiency: 18-month response to recombinant human growth hormone.Hormones (Athens)202642449097PubTator, text miningPubMed

1 to 10 of 2,806

See all 2,806 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5573

GET https://conductscience.org/api/genes/v1/5573/patents?page=2