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Gene · 55737

VPS35: VPS35 retromer complex component

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. VPS35: VPS35 retromer complex component. Genes, record 55737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55737

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Gene

Symbol
VPS35
HGNC
Name
VPS35 retromer complex component
HGNC
NCBI Gene ID
55737
NCBI Gene
HGNC ID
HGNC:13487
HGNC
Ensembl
ENSG00000069329
NCBI Gene
Aliases
FLJ10752, MEM3, PARK17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96QK1Vacuolar protein sorting-associated protein 3579613Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12570963 B22026-03-1049Q96QK1Espacenet
JP 2026004568 A2026-01-1469485Q96QK1Espacenet
US 12516298 B22026-01-0649Q96QK1Espacenet
EP 4650780 A22025-11-193912Q96QK1Espacenet
EP 4641201 A22025-10-293493Q96QK1Espacenet
JP 2025149978 A2025-10-081Q96QK1Espacenet
JP 2025517969 A2025-06-123493Q96QK1Espacenet
JP 2025517970 A2025-06-123912Q96QK1Espacenet
JP 2025062601 A2025-04-1445Q96QK1Espacenet
JP 2025016496 A2025-02-0449Q96QK1Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,344

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleVPS35 papersNewest fiscal year
ZIAHD001607Protein Trafficking In The Endosomal-Lysosomal System102025
R35GM119525Molecular mechanisms of coat assembly and regulation in membrane trafficking pathways82025
ZIANS003154Genetic characterization of atypical parkinsonism72025
P30AG066462Alzheimer's Disease Research Center52025
P40OD010440Caenorhabditis Genetics Center42025
P40OD018537Bloomington Drosophila Stock Center at Indiana University42025
R01NS060123Neuronal Autophagy: a Cell-Autonomous Protection Mechanism42025
R35GM128786Signal Integration from Membranes to the Actin Cytoskeleton42025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.32025
P30CA008748Cancer Center Support Grant32025

1 to 10 of 1,344Source NIH's project files

See all 1,344 nih grants

Papers2,077

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular mechanisms of Microcystin-LR decreasing dopamine release by binding VPS35 and clinical correlation between Microcystin-LR exposure and Parkinson's disease.J Environ Sci (China)202642822928PubTator, text miningPubMed
BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer interactions.Proc Natl Acad Sci U S A202642804638PubTator, text miningPubMed
Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets.Metab Brain Dis202642803978PubTator, text miningPubMed
TRIM62 facilitates influenza A virus entry by regulating WASH-dependent endosomal trafficking.EMBO Rep202642763336PubTator, text miningPubMed
Retromer-targeted therapy for neurodegenerative diseases.Mol Neurodegener202642723096PubTator, text miningPubMed
Exploring cerebral small vessel disease signatures in familial Parkinson's disease.Sci Rep202642706363PubTator, text miningPubMed
Targeting VPS35 increases chemotherapy sensitivity in gastric cancer cells via regulation of the NF-κB signaling pathway.Cancer Gene Ther202642624899PubTator, text miningPubMed
Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.Lancet Neurol202642456684PubTator, text miningPubMed
SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism.Cell Rep202642287635PubTator, text miningPubMed
The N6-methyladenosine reader IGF2BP2 in T-cell lymphoma.Blood202642166364PubTator, text miningPubMed

1 to 10 of 2,077

See all 2,077 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/55737

GET https://conductscience.org/api/genes/v1/55737/patents?page=2