Gene · 55737
VPS35: VPS35 retromer complex component
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. VPS35: VPS35 retromer complex component. Genes, record 55737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55737
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96QK1 | Vacuolar protein sorting-associated protein 35 | 796 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12570963 B2 | 2026-03-10 | 49 | Q96QK1 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 69485 | Q96QK1 | Espacenet |
| US 12516298 B2 | 2026-01-06 | 49 | Q96QK1 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3912 | Q96QK1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3493 | Q96QK1 | Espacenet |
| JP 2025149978 A | 2025-10-08 | 1 | Q96QK1 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3493 | Q96QK1 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3912 | Q96QK1 | Espacenet |
| JP 2025062601 A | 2025-04-14 | 45 | Q96QK1 | Espacenet |
| JP 2025016496 A | 2025-02-04 | 49 | Q96QK1 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,344
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | VPS35 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD001607 | Protein Trafficking In The Endosomal-Lysosomal System | 10 | 2025 |
| R35GM119525 | Molecular mechanisms of coat assembly and regulation in membrane trafficking pathways | 8 | 2025 |
| ZIANS003154 | Genetic characterization of atypical parkinsonism | 7 | 2025 |
| P30AG066462 | Alzheimer's Disease Research Center | 5 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 4 | 2025 |
| P40OD018537 | Bloomington Drosophila Stock Center at Indiana University | 4 | 2025 |
| R01NS060123 | Neuronal Autophagy: a Cell-Autonomous Protection Mechanism | 4 | 2025 |
| R35GM128786 | Signal Integration from Membranes to the Actin Cytoskeleton | 4 | 2025 |
| P20GM121176 | Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2. | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,344Source NIH's project files
See all 1,344 nih grantsPapers2,077
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Molecular mechanisms of Microcystin-LR decreasing dopamine release by binding VPS35 and clinical correlation between Microcystin-LR exposure and Parkinson's disease. | J Environ Sci (China) | 2026 | 42822928 | PubTator, text mining | PubMed |
| BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer interactions. | Proc Natl Acad Sci U S A | 2026 | 42804638 | PubTator, text mining | PubMed |
| Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets. | Metab Brain Dis | 2026 | 42803978 | PubTator, text mining | PubMed |
| TRIM62 facilitates influenza A virus entry by regulating WASH-dependent endosomal trafficking. | EMBO Rep | 2026 | 42763336 | PubTator, text mining | PubMed |
| Retromer-targeted therapy for neurodegenerative diseases. | Mol Neurodegener | 2026 | 42723096 | PubTator, text mining | PubMed |
| Exploring cerebral small vessel disease signatures in familial Parkinson's disease. | Sci Rep | 2026 | 42706363 | PubTator, text mining | PubMed |
| Targeting VPS35 increases chemotherapy sensitivity in gastric cancer cells via regulation of the NF-κB signaling pathway. | Cancer Gene Ther | 2026 | 42624899 | PubTator, text mining | PubMed |
| Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications. | Lancet Neurol | 2026 | 42456684 | PubTator, text mining | PubMed |
| SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism. | Cell Rep | 2026 | 42287635 | PubTator, text mining | PubMed |
| The N6-methyladenosine reader IGF2BP2 in T-cell lymphoma. | Blood | 2026 | 42166364 | PubTator, text mining | PubMed |
1 to 10 of 2,077
See all 2,077 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/55737
GET https://conductscience.org/api/genes/v1/55737/patents?page=2