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Gene · 55768

NGLY1: N-glycanase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NGLY1: N-glycanase 1. Genes, record 55768. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55768

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Gene

Symbol
NGLY1
HGNC
Name
N-glycanase 1
HGNC
NCBI Gene ID
55768
NCBI Gene
HGNC ID
HGNC:17646
HGNC
Ensembl
ENSG00000151092
NCBI Gene
Aliases
CDDG, CDG1V, FLJ11005, PNG-1, PNG1, PNGase
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96IV0Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase6542Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21229Q96IV0Espacenet
JP 2026004568 A2026-01-1455659Q96IV0Espacenet
EP 4650780 A22025-11-193096Q96IV0Espacenet
EP 4641201 A22025-10-292654Q96IV0Espacenet
JP 2025147176 A2025-10-069357Q96IV0Espacenet
JP 2025529142 A2025-09-042833Q96IV0Espacenet
JP 2025529142 A2025-09-047138Q96IV0Espacenet
US 12371689 B22025-07-292833Q96IV0Espacenet
US 12371689 B22025-07-297138Q96IV0Espacenet
JP 2025517969 A2025-06-122654Q96IV0Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,502

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNGLY1 papersNewest fiscal year
ZIATR000018Drug Repurposing Screening for Rare and Neglected Diseases72025
P30CA016672Cancer Center Support Grant62025
R35GM130317Roles of Glycosylation and Deglycosylation During Animal Development52025
P30AI060354Harvard University Center for AIDS Research42025
P30CA016042Cancer Center Support Grant42025
P40OD018537Bloomington Drosophila Stock Center at Indiana University42025
P30AI027767UAB Center for AIDS Research (CFAR)32025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant32025
P30DK123704MUSC Digestive Disease Research Core Center32025
R01AG016636Genetic and Molecular Basis of Longevity32025

1 to 10 of 1,502Source NIH's project files

See all 1,502 nih grants

Papers2,225

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Impacts of N-glycanase1 (NGLY1) Down Regulation on the Function of Mitochondria.J Cell Biochem202642634536PubTator, text miningPubMed
Epigenomewide Association Study of Monozygotic Twins Reveals That Serum Uric Acid Influences DNA Methylation.Twin Res Hum Genet202642165100PubTator, text miningPubMed
Discovering the Hidden Power of NGLY1: Orchestrating Immune Cell Functions and Autoimmune Diseases.Front Biosci (Landmark Ed)202642052850PubTator, text miningPubMed
VE-cadherin interaction proteomics identifies ARVCF as stabilizer of endothelial adherens junctions.iScience202642006337PubTator, text miningPubMed
Cytosolic Peptide: N-Glycanase (NGLY1)-from Basic Biology to Genetic Disorder, NGLY1 Deficiency.Adv Exp Med Biol202641917400PubTator, text miningPubMed
Nrf3: an emerging player in cancer, inflammation, and cellular homeostasis.Mol Biol Rep202641838283PubTator, text miningPubMed
Directed evolution of Clec12a-binding peptides using mammalian-expressed recombinant protein.Biochem Biophys Rep202641799695PubTator, text miningPubMed
Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome.J Hum Immun202641783139PubTator, text miningPubMed
The Role of Glycan Structures in Modulating GM-CSF Bioactivity: Insights from Glycoengineering.bioRxiv202641756846PubTator, text miningPubMed
Myoclonus in Pediatric Metabolic Diseases: Clinical Spectrum, Mechanisms, and Treatable Causes-A Systematic Review.Metabolites202641745581PubTator, text miningPubMed

1 to 10 of 2,225

See all 2,225 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/55768

GET https://conductscience.org/api/genes/v1/55768/patents?page=2