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PRKCB: protein kinase C beta

1 protein, 70 patents, 8 drugs, 119 trials, 3,476 NIH grants and 5,660 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRKCBHGNC
Nameprotein kinase C betaHGNC
NCBI Gene ID5579NCBI Gene
HGNC IDHGNC:9395HGNC
EnsemblENSG00000166501NCBI Gene
AliasesPKC-beta, PKCB, PKCI(2), PKCbeta, PKCβ, PRKCB1, PRKCB2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05771Protein kinase C beta type6718Ensembl, GeneID, HGNCUniProt

Patents 70

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-294767P05771Espacenet
JP 2025524002 A2025-07-255P05771Espacenet
JP 2025517969 A2025-06-124767P05771Espacenet
KR 1020250039465 A2025-03-205P05771Espacenet
JP 2025032204 A2025-03-1134050P05771Espacenet
EP 4461818 A22024-11-1334050P05771Espacenet
US 12130292 B22024-10-2932P05771Espacenet
JP 2024123008 A2024-09-107851P05771Espacenet
JP 2024023699 A2024-02-215P05771Espacenet
JP 2024505890 A2024-02-085P05771Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEP-2563CHEMBL6069183Protein kinase C (PKC) inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Protein kinase C (PKC) inhibitorINHIBITORChEMBL
ENZASTAURINCHEMBL300138Protein kinase C beta inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Protein kinase C (PKC) inhibitorINHIBITORChEMBL
MIDOSTAURINCHEMBL608533Protein kinase C (PKC) inhibitorINHIBITORChEMBL
RUBOXISTAURINCHEMBL91829Protein kinase C beta inhibitorINHIBITORChEMBL
SOTRASTAURINCHEMBL565612Protein kinase C (PKC) inhibitorINHIBITORChEMBL
UCN-01CHEMBL574737Protein kinase C (PKC) inhibitorINHIBITORChEMBL

Trials 119

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT06313437MIDOSTAURINPHASE1ClinicalTrials.gov
NCT05219266MIDOSTAURINClinicalTrials.gov
NCT04982354MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04496999MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04385290MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04174612MIDOSTAURINPHASE3ClinicalTrials.gov
NCT04097470MIDOSTAURINPHASE2ClinicalTrials.gov
NCT04075747MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04027309MIDOSTAURINPHASE3ClinicalTrials.gov

NIH grants 3476

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant272,025NIH's project files
P30DK036836Diabetes Research Center162,025NIH's project files
P30CA016058Cancer Center Support Grant122,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
R35GM122523Molecular Mechanisms of Cell Signaling102,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)82,025NIH's project files
ZIABC011008Oncogenic mechanisms and molecular targets in lymphoma82,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant72,025NIH's project files
P30CA068485Cancer Center Support Grant72,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant62,025NIH's project files

Papers 5660

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42792915PubTator, text miningPubMed
42781997PubTator, text miningPubMed
42753351PubTator, text miningPubMed
42751806PubTator, text miningPubMed
42749797PubTator, text miningPubMed
42697978PubTator, text miningPubMed
42683062PubTator, text miningPubMed
42591530PubTator, text miningPubMed
42542590PubTator, text miningPubMed
42510635PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license