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PRKCE: protein kinase C epsilon

1 protein, 84 patents, 7 drugs, 73 trials, 3,871 NIH grants and 5,702 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRKCEHGNC
Nameprotein kinase C epsilonHGNC
NCBI Gene ID5581NCBI Gene
HGNC IDHGNC:9401HGNC
EnsemblENSG00000171132NCBI Gene
AliasesPKCE, PKCepsilon, PKCε, nPKC-epsilonNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q02156Protein kinase C epsilon type7372Ensembl, GeneID, HGNCUniProt

Patents 84

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2025245188 A22025-11-2716Q02156Espacenet
EP 4650780 A22025-11-194401Q02156Espacenet
EP 4641201 A22025-10-293944Q02156Espacenet
JP 2025517969 A2025-06-123944Q02156Espacenet
JP 2025517970 A2025-06-124401Q02156Espacenet
JP 2024123008 A2024-09-107853Q02156Espacenet
US 11892452 B22024-02-06105Q02156Espacenet
JP 2023510565 A2023-03-14211Q02156Espacenet
US 11446398 B22022-09-2068202Q02156Espacenet
JP 2022524081 A2022-04-27171173Q02156Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEP-2563CHEMBL6069183Protein kinase C (PKC) inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Protein kinase C (PKC) inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Protein kinase C (PKC) inhibitorINHIBITORChEMBL
KAI-1678CHEMBL4297775Protein kinase C epsilon inhibitorINHIBITORChEMBL
MIDOSTAURINCHEMBL608533Protein kinase C (PKC) inhibitorINHIBITORChEMBL
SOTRASTAURINCHEMBL565612Protein kinase C (PKC) inhibitorINHIBITORChEMBL
UCN-01CHEMBL574737Protein kinase C (PKC) inhibitorINHIBITORChEMBL

Trials 73

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT06313437MIDOSTAURINPHASE1ClinicalTrials.gov
NCT05219266MIDOSTAURINClinicalTrials.gov
NCT04982354MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04496999MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04385290MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04174612MIDOSTAURINPHASE3ClinicalTrials.gov
NCT04097470MIDOSTAURINPHASE2ClinicalTrials.gov
NCT04075747MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04027309MIDOSTAURINPHASE3ClinicalTrials.gov

NIH grants 3871

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK045735Yale Diabetes Research Center382,025NIH's project files
P30CA016672Cancer Center Support Grant272,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award242,025NIH's project files
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease222,025NIH's project files
R01NS034773ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTION192,025NIH's project files
P30DK034989Yale Liver Center132,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support122,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant102,025NIH's project files
U54OH010162Surveillance of Agricultural Injuries in the Central States Regions92,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase72,025NIH's project files

Papers 5702

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42792990PubTator, text miningPubMed
42475286PubTator, text miningPubMed
42436976PubTator, text miningPubMed
42282530PubTator, text miningPubMed
42108706PubTator, text miningPubMed
42107084PubTator, text miningPubMed
42044228PubTator, text miningPubMed
41947728PubTator, text miningPubMed
41894254PubTator, text miningPubMed
41883368PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license