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Gene · 5582

PRKCG: protein kinase C gamma

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRKCG: protein kinase C gamma. Genes, record 5582. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5582

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Gene

Symbol
PRKCG
HGNC
Name
protein kinase C gamma
HGNC
NCBI Gene ID
5582
NCBI Gene
HGNC ID
HGNC:9402
HGNC
Ensembl
ENSG00000126583
NCBI Gene
Aliases
MGC57564, PKC-gamma, PKCC, PKCG, PKCI(3), PKCgamma, PKCγ, SCA14
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05129Protein kinase C gamma type6972Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-291780P05129Espacenet
JP 2025517969 A2025-06-121780P05129Espacenet
JP 2025032204 A2025-03-1134063P05129Espacenet
EP 4461818 A22024-11-1334063P05129Espacenet
JP 2024123008 A2024-09-107855P05129Espacenet
US 11892452 B22024-02-06103P05129Espacenet
JP 2023058610 A2023-04-2534063P05129Espacenet
JP 2023513275 A2023-03-301P05129Espacenet
US 11446398 B22022-09-2068219P05129Espacenet
US 11360101 B22022-06-141P05129Espacenet

1 to 10 of 48

See all 48 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEP-2563CHEMBL6069183Protein kinase C (PKC) inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Protein kinase C (PKC) inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Protein kinase C (PKC) inhibitorINHIBITORChEMBL
MIDOSTAURINCHEMBL608533Protein kinase C (PKC) inhibitorINHIBITORChEMBL
SOTRASTAURINCHEMBL565612Protein kinase C (PKC) inhibitorINHIBITORChEMBL
UCN-01CHEMBL574737Protein kinase C (PKC) inhibitorINHIBITORChEMBL

Trials71

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT06313437MIDOSTAURINPHASE1ClinicalTrials.gov
NCT05219266MIDOSTAURINClinicalTrials.gov
NCT04982354MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04496999MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04385290MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04174612MIDOSTAURINPHASE3ClinicalTrials.gov
NCT04097470MIDOSTAURINPHASE2ClinicalTrials.gov
NCT04075747MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04027309MIDOSTAURINPHASE3ClinicalTrials.gov

1 to 10 of 71

See all 71 trials

NIH grants1,455

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRKCG papersNewest fiscal year
R35GM122523Molecular Mechanisms of Cell Signaling82025
P30CA016672Cancer Center Support Grant62025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant42025
R01NS120725Structural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar Ataxia42025
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders32025
R01NS124854Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential Tremor32025
T32MH020017Ph.D. Training in Neuroscience32025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR22025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 1,455Source NIH's project files

See all 1,455 nih grants

Papers1,943

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Protein Kinase C-fused blue naevi with gene rearrangements involving PRKCD, PRKCQ, and PRKCG: expanding the genetic spectrum of an uncommon entity.Pathology202642827077PubTator, text miningPubMed
To Prune or to Protect: Complement-Mediated Microglial Synaptic Pruning as a Therapeutic Target in Neuropathic Pain.Mol Neurobiol202642732533PubTator, text miningPubMed
SUMOylation-Driven Subtype Heterogeneity and Prognostic Biomarkers in Renal Cell Carcinoma.Curr Issues Mol Biol202642651750PubTator, text miningPubMed
Divergent somatic mutation patterns among human cerebellar neuron types.Neuron202642575091PubTator, text miningPubMed
Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development.iScience202642572605PubTator, text miningPubMed
Experimental and Computational Insights into the Apoptotic Potential of New Phenanthroline-Based Copper(II) Complexes: From Spectroscopic Characterization and In Vitro Cytotoxicity to In Silico Target Identification.
Biomedicines202642512097PubTator, text miningPubMed
Plasma Proteins and Genes Associated with Protein and Risks for Diabetic Foot Diseases Identified Using Multi- Ornics and Mendelian Randomization Analysis.Curr Med Chem202642509680PubTator, text miningPubMed
Rare 19q13.42 duplication encompassing PRKCG associated with neurodevelopmental abnormalities.Transl Pediatr202642292632PubTator, text miningPubMed
Inhibition of PKCγ phosphorylation protects against cerebral ischemia-reperfusion injury.Redox Biol202642217276PubTator, text miningPubMed
Chronic stress drives gastric cancer lymph node metastasis via NETosis through a feedforward ACh-NGF axis-mediated PKC-γ/STAT3 pathway.Oncogene202642215706PubTator, text miningPubMed

1 to 10 of 1,943

See all 1,943 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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