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Gene · 55851

PSENEN: presenilin enhancer, gamma-secretase subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSENEN: presenilin enhancer, gamma-secretase subunit. Genes, record 55851. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55851

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Gene

Symbol
PSENEN
HGNC
Name
presenilin enhancer, gamma-secretase subunit
HGNC
NCBI Gene ID
55851
NCBI Gene
HGNC ID
HGNC:30100
HGNC
Ensembl
ENSG00000205155
NCBI Gene
Aliases
ACNINV2, MDS033, MSTP064, PEN-2, PEN2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NZ42Gamma-secretase subunit PEN-210127Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459039Q9NZ42Espacenet
JP 2026004568 A2026-01-1459040Q9NZ42Espacenet
EP 4650780 A22025-11-19546Q9NZ42Espacenet
JP 2025529142 A2025-09-043602Q9NZ42Espacenet
US 12371689 B22025-07-293602Q9NZ42Espacenet
JP 2025517970 A2025-06-12546Q9NZ42Espacenet
US 11446398 B22022-09-2066560Q9NZ42Espacenet
US 11446398 B22022-09-2066561Q9NZ42Espacenet
US 11400116 B22022-08-027440Q9NZ42Espacenet
JP 2022524081 A2022-04-27169531Q9NZ42Espacenet

1 to 10 of 48

See all 48 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVAGACESTATCHEMBL1090771Gamma-secretase inhibitorINHIBITORChEMBL
BEGACESTATCHEMBL463981Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTATCHEMBL1770916Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTAT HYDROBROMIDECHEMBL4298153Gamma-secretase inhibitorINHIBITORChEMBL
RG-4733CHEMBL4297422Gamma-secretase inhibitorINHIBITORChEMBL
SEMAGACESTATCHEMBL520733Gamma-secretase inhibitorINHIBITORChEMBL
TARENFLURBILCHEMBL190083Gamma-secretase modulatorMODULATORChEMBL

Trials67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07539454NIROGACESTATPHASE2ClinicalTrials.gov
NCT07176689NIROGACESTATPHASE4ClinicalTrials.gov
NCT07170644NIROGACESTATPHASE2ClinicalTrials.gov
NCT07150104NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07150091NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07084896NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05949099NIROGACESTATPHASE2ClinicalTrials.gov
NCT05879146NIROGACESTATPHASE2ClinicalTrials.gov
NCT05573802NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05556798NIROGACESTATPHASE1ClinicalTrials.gov

1 to 10 of 67

See all 67 trials

NIH grants839

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSENEN papersNewest fiscal year
P30CA008748Cancer Center Support Grant122025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)72025
P30CA168524The University of Kansas Cancer Center52025
ZIAAG000311ALZHEIMERS RESEARCH PROJECT: Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)42025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study32025
P30CA016672Cancer Center Support Grant32025
T32AG000222Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease32025
U19AG032438Bridge Funding for Dominantly Inherited Alzheimer Network32025
U54CA1323781/2 CCNY-MSK Partnership for Cancer Research, Education and Community Outreach32025
U54CA1377882/2 CCNY-MSKCC Partnership for Cancer Research, Education and Community Outreach32025

1 to 10 of 839Source NIH's project files

See all 839 nih grants

Papers1,301

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Systemic Molecular Network Alterations Associated with FoxA2 in Gastric Cancer.Int J Mol Sci202642511485PubTator, text miningPubMed
Differential DNA Methylation and Delirium After Anesthesia and Surgery.medRxiv202642369472PubTator, text miningPubMed
Metformin Redirects Autophagy from Bulk Turnover to Mitochondrial Clearance.bioRxiv202642282636PubTator, text miningPubMed
Penetratin: Structure and Interactions with Lipid Membranes of Various Compositions.J Phys Chem B202641960875PubTator, text miningPubMed
Metformin Regulation of the Liver Circadian Clock and Metabolic Aging: A Systems Modeling Study.Metabolites202641893357PubTator, text miningPubMed
Exploring Gene Expression Patterns in Alzheimer's Disease Using a Human Microarray Data Meta-Analysis.Biology (Basel)202641744654PubTator, text miningPubMed
β-amyloid and β-amyloid precursor protein synthesis and processing: effects of exercise and exercise-related injury.Front Cell Neurosci202641737532PubTator, text miningPubMed
Whole blood gene expression moderates associations between AD biomarkers and cognitive decline in cognitively unimpaired older adults.Alzheimers Dement202641724695PubTator, text miningPubMed
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2.Neuromolecular Med202641615513PubTator, text miningPubMed
The role of metformin in extracellular matrix-based three-dimensional cell culture Models: A mini-review on therapeutic potentials.Biochem Biophys Rep202641561225PubTator, text miningPubMed

1 to 10 of 1,301

See all 1,301 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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