ConductScience.org, home

Gene · 55869

HDAC8: histone deacetylase 8

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HDAC8: histone deacetylase 8. Genes, record 55869. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55869

On this page

Gene

Symbol
HDAC8
HGNC
Name
histone deacetylase 8
HGNC
NCBI Gene ID
55869
NCBI Gene
HGNC ID
HGNC:13315
HGNC
Ensembl
ENSG00000147099
NCBI Gene
Aliases
CDA07, CDLS5, HD8, HDACL1, KDAC8, MRXS6, RPD3, WTS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BY41Histone deacetylase 837753Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199334Q9BY41Espacenet
EP 4641201 A22025-10-299576Q9BY41Espacenet
JP 2025517969 A2025-06-129576Q9BY41Espacenet
JP 2025517970 A2025-06-129334Q9BY41Espacenet
JP 2025032204 A2025-03-1129492Q9BY41Espacenet
EP 4461818 A22024-11-1329492Q9BY41Espacenet
JP 2024123008 A2024-09-106490Q9BY41Espacenet
JP 2024525725 A2024-07-1218Q9BY41Espacenet
EP 4370698 A12024-05-2218Q9BY41Espacenet
JP 2024507735 A2024-02-21124Q9BY41Espacenet

1 to 10 of 37

See all 37 patents

Drugs13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
MOCETINOSTATCHEMBL272980Histone deacetylase 8 inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL

1 to 10 of 13

See all 13 drugs

Trials410

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT06824662QUISINOSTATEARLY_PHASE1ClinicalTrials.gov
NCT06769633GIVINOSTAT HYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT06561048BELINOSTATPHASE3ClinicalTrials.gov
NCT06406465BELINOSTATPHASE2ClinicalTrials.gov
NCT06240520PANOBINOSTATPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 410

See all 410 trials

NIH grants1,662

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHDAC8 papersNewest fiscal year
R01GM049758Structure and Function of Metalloenzymes362025
P30CA016672Cancer Center Support Grant112025
P30CA008748Cancer Center Support Grant82025
P30CA076292Moffitt Cancer Center Support Grant82025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography72025
P30CA022453CANCER CENTER SUPPORT GRANT52025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)52025
P30AI050410The University of North Carolina Center for AIDS Research42025
P30CA014520UW Comprehensive Cancer Center Support42025
P20GM130459Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System32025

1 to 10 of 1,662Source NIH's project files

See all 1,662 nih grants

Papers3,134

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery of cyanocarbonimidodithioates as novel non-hydroxamate zinc-binding groups for selective HDAC8 inhibition: Design, synthesis, biological evaluation, anticancer activity, and in silico studies.
Bioorg Chem202642767177PubTator, text miningPubMed
Accelerating HDAC8 inhibitor discovery through deep learning, cheminformatics, docking, and molecular dynamics simulations.J Mol Graph Model202642732699PubTator, text miningPubMed
Design, synthesis, and screening of novel thienopyrimidine derivatives as PI3K/HDAC dual inhibitors against cervical cancer cells.Eur J Med Chem202642715866PubTator, text miningPubMed
Tumor-intrinsic NSUN2 orchestrates immunosuppression in lung adenocarcinoma via the m5C-HDAC8-CCL5 axis.Exp Hematol Oncol202642706582PubTator, text miningPubMed
Evaluation of HDAC8 as a Druggable Target in STAG2-Mutant Ewing Sarcoma.ACS Chem Biol202642677456PubTator, text miningPubMed
Fast-Food Component-Induced Epigenetic Modifications Modulate Immunotherapy in Metastatic Breast Cancer.ACS Omega202642662312PubTator, text miningPubMed
Expression of HDAC2 and HDAC8 in the airways of COPD patients is associated with responsiveness to ICS: insights from the HISTORIC study.Eur Respir J202642660606PubTator, text miningPubMed
Design, one-pot synthesis, and structural characterization of novel 2-ureido-6-nitrobenzamide derivatives as MTDLs targeting HDAC8/epigenetic-kinase networks.Bioorg Chem202642641237PubTator, text miningPubMed
Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors.RSC Adv202642614841PubTator, text miningPubMed
Fusion-subtype and single-cell analyses refine the interpretation of HDAC8 dependency in KMT2A-rearranged AML.Leukemia202642567883PubTator, text miningPubMed

1 to 10 of 3,134

See all 3,134 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/55869

GET https://conductscience.org/api/genes/v1/55869/patents?page=2