Gene · 5587
PRKD1: protein kinase D1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PRKD1: protein kinase D1. Genes, record 5587. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5587
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15139 | Serine/threonine-protein kinase D1 | 912 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents62
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59737 | Q15139 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6027 | Q15139 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 23311 | Q15139 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5768 | Q15139 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10802 | Q15139 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10803 | Q15139 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7432 | Q15139 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7432 | Q15139 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5768 | Q15139 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 23311 | Q15139 | Espacenet |
1 to 10 of 62
See all 62 patentsDrugs6
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| CEP-2563 | CHEMBL6069183 | Protein kinase C (PKC) inhibitor | INHIBITOR | ChEMBL |
| CEP-2563 DIHYDROCHLORIDE | CHEMBL6067987 | Protein kinase C (PKC) inhibitor | INHIBITOR | ChEMBL |
| GSK-690693 | CHEMBL494089 | Protein kinase C (PKC) inhibitor | INHIBITOR | ChEMBL |
| MIDOSTAURIN | CHEMBL608533 | Protein kinase C (PKC) inhibitor | INHIBITOR | ChEMBL |
| SOTRASTAURIN | CHEMBL565612 | Protein kinase C (PKC) inhibitor | INHIBITOR | ChEMBL |
| UCN-01 | CHEMBL574737 | Protein kinase C (PKC) inhibitor | INHIBITOR | ChEMBL |
Trials71
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07572695 | MIDOSTAURIN | ClinicalTrials.gov | ||
| NCT06313437 | MIDOSTAURIN | PHASE1 | ClinicalTrials.gov | |
| NCT05219266 | MIDOSTAURIN | ClinicalTrials.gov | ||
| NCT04982354 | MIDOSTAURIN | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04496999 | MIDOSTAURIN | PHASE1 | ClinicalTrials.gov | |
| NCT04385290 | MIDOSTAURIN | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04174612 | MIDOSTAURIN | PHASE3 | ClinicalTrials.gov | |
| NCT04097470 | MIDOSTAURIN | PHASE2 | ClinicalTrials.gov | |
| NCT04075747 | MIDOSTAURIN | PHASE1 | ClinicalTrials.gov | |
| NCT04027309 | MIDOSTAURIN | PHASE3 | ClinicalTrials.gov |
1 to 10 of 71
See all 71 trialsNIH grants2,521
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PRKD1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 21 | 2025 |
| P50CA116201 | Mayo Clinic Breast Cancer SPORE | 14 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| ZIADK053101 | Cellular Basis Of Action Of Gastrointestinal Peptides/Growth factors | 8 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 6 | 2025 |
| T32HL007444 | Training in Cardiovascular Physiology and Pharmacology | 6 | 2025 |
| P2CHD050924 | Carolina Population Center | 5 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 5 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 2,521Source NIH's project files
See all 2,521 nih grantsPapers3,376
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cholinergic activation of HLH-30/TFEB promotes C. elegans infection resilience. | bioRxiv | 2026 | 42818098 | PubTator, text mining | PubMed |
| Expanding the Phenotypic Spectrum of PRKD1 Gain-of-Function Syndrome: Congenital Heart Disease, Bilateral Carotid Dissections, and Ectodermal Dysplasia in an Adult Patient. | Genes (Basel) | 2026 | 42792942 | PubTator, text mining | PubMed |
| Protein kinase D1 regulates innate immune signaling pathways to promote hepatitis C virus replication. | J Virol | 2026 | 42714215 | PubTator, text mining | PubMed |
| Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral testing in flaviviruses. | Antiviral Res | 2026 | 42685838 | PubTator, text mining | PubMed |
| Visualization of membrane-stabilized SorCS2 cis interactions. | J Struct Biol X | 2026 | 42568954 | PubTator, text mining | PubMed |
| Mechanical forces stimulate Golgi export. | J Cell Biol | 2026 | 42506967 | PubTator, text mining | PubMed |
| Hybrid Approach to Protein-Protein Complex Affinity Prediction Based on Language Models and Molecular Dynamics. | Int J Mol Sci | 2026 | 42450193 | PubTator, text mining | PubMed |
| Pathophysiological affair between protein kinase D and epithelial ovarian cancer: A roadmap towards translating the mechanism from bench to bedside. | Biochim Biophys Acta Rev Cancer | 2026 | 42425229 | PubTator, text mining | PubMed |
| Deep contrastive learning framework identifies cell-type-specific drug targets in Alzheimer's disease. | Alzheimers Dement (Amst) | 2026 | 42382038 | PubTator, text mining | PubMed |
| Aldose Reductase Inhibitor, Epalrestat, Suppresses Colorectal Cancer Cell Proliferation Through Complement-Dependent Cytotoxicity. | Int J Toxicol | 2026 | 42372195 | PubTator, text mining | PubMed |
1 to 10 of 3,376
See all 3,376 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5587
GET https://conductscience.org/api/genes/v1/5587/patents?page=2