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Gene · 5587

PRKD1: protein kinase D1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRKD1: protein kinase D1. Genes, record 5587. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5587

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Gene

Symbol
PRKD1
HGNC
Name
protein kinase D1
HGNC
NCBI Gene ID
5587
NCBI Gene
HGNC ID
HGNC:9407
HGNC
Ensembl
ENSG00000184304
NCBI Gene
Aliases
CHDED, PKC-MU, PKC-mu, PKCM, PKD, PKD1, PRKCM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15139Serine/threonine-protein kinase D19120Ensembl, GeneID, HGNC

Source UniProt

Patents62

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459737Q15139Espacenet
EP 4650780 A22025-11-196027Q15139Espacenet
EP 4641201 A22025-10-2923311Q15139Espacenet
EP 4641201 A22025-10-295768Q15139Espacenet
JP 2025147176 A2025-10-0610802Q15139Espacenet
JP 2025147176 A2025-10-0610803Q15139Espacenet
JP 2025529142 A2025-09-047432Q15139Espacenet
US 12371689 B22025-07-297432Q15139Espacenet
JP 2025517969 A2025-06-125768Q15139Espacenet
JP 2025517969 A2025-06-1223311Q15139Espacenet

1 to 10 of 62

See all 62 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEP-2563CHEMBL6069183Protein kinase C (PKC) inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Protein kinase C (PKC) inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Protein kinase C (PKC) inhibitorINHIBITORChEMBL
MIDOSTAURINCHEMBL608533Protein kinase C (PKC) inhibitorINHIBITORChEMBL
SOTRASTAURINCHEMBL565612Protein kinase C (PKC) inhibitorINHIBITORChEMBL
UCN-01CHEMBL574737Protein kinase C (PKC) inhibitorINHIBITORChEMBL

Trials71

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT06313437MIDOSTAURINPHASE1ClinicalTrials.gov
NCT05219266MIDOSTAURINClinicalTrials.gov
NCT04982354MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04496999MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04385290MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04174612MIDOSTAURINPHASE3ClinicalTrials.gov
NCT04097470MIDOSTAURINPHASE2ClinicalTrials.gov
NCT04075747MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04027309MIDOSTAURINPHASE3ClinicalTrials.gov

1 to 10 of 71

See all 71 trials

NIH grants2,521

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRKD1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant212025
P50CA116201Mayo Clinic Breast Cancer SPORE142025
P30CA016672Cancer Center Support Grant92025
ZIADK053101Cellular Basis Of Action Of Gastrointestinal Peptides/Growth factors82025
P50AA011999Southern California Research Center for ALPD and Cirrhosis62025
T32HL007444Training in Cardiovascular Physiology and Pharmacology62025
P2CHD050924Carolina Population Center52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA006973Regional Oncology Research Center52025
P30CA023168Cancer Center Support Grant52025

1 to 10 of 2,521Source NIH's project files

See all 2,521 nih grants

Papers3,376

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cholinergic activation of HLH-30/TFEB promotes C. elegans infection resilience.bioRxiv202642818098PubTator, text miningPubMed
Expanding the Phenotypic Spectrum of PRKD1 Gain-of-Function Syndrome: Congenital Heart Disease, Bilateral Carotid Dissections, and Ectodermal Dysplasia in an Adult Patient.Genes (Basel)202642792942PubTator, text miningPubMed
Protein kinase D1 regulates innate immune signaling pathways to promote hepatitis C virus replication.J Virol202642714215PubTator, text miningPubMed
Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral testing in flaviviruses.Antiviral Res202642685838PubTator, text miningPubMed
Visualization of membrane-stabilized SorCS2 cis interactions.J Struct Biol X202642568954PubTator, text miningPubMed
Mechanical forces stimulate Golgi export.J Cell Biol202642506967PubTator, text miningPubMed
Hybrid Approach to Protein-Protein Complex Affinity Prediction Based on Language Models and Molecular Dynamics.Int J Mol Sci202642450193PubTator, text miningPubMed
Pathophysiological affair between protein kinase D and epithelial ovarian cancer: A roadmap towards translating the mechanism from bench to bedside.Biochim Biophys Acta Rev Cancer202642425229PubTator, text miningPubMed
Deep contrastive learning framework identifies cell-type-specific drug targets in Alzheimer's disease.Alzheimers Dement (Amst)202642382038PubTator, text miningPubMed
Aldose Reductase Inhibitor, Epalrestat, Suppresses Colorectal Cancer Cell Proliferation Through Complement-Dependent Cytotoxicity.Int J Toxicol202642372195PubTator, text miningPubMed

1 to 10 of 3,376

See all 3,376 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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