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Gene · 55876

GSDMB: gasdermin B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GSDMB: gasdermin B. Genes, record 55876. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55876

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Gene

Symbol
GSDMB
HGNC
Name
gasdermin B
HGNC
NCBI Gene ID
55876
NCBI Gene
HGNC ID
HGNC:23690
HGNC
Ensembl
ENSG00000073605
NCBI Gene
Aliases
GSDMB-1, GSDML, PP4052, PRO2521
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TAX9Gasdermin-B41611Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447381Q8TAX9Espacenet
EP 4640849 A22025-10-291171Q8TAX9Espacenet
EP 4641201 A22025-10-297834Q8TAX9Espacenet
WO 2025132695 A12025-06-2646Q8TAX9Espacenet
JP 2025519096 A2025-06-241171Q8TAX9Espacenet
JP 2025517969 A2025-06-127834Q8TAX9Espacenet
US 11679140 B22023-06-2029Q8TAX9Espacenet
US 11446398 B22022-09-2034155Q8TAX9Espacenet
US 11446398 B22022-09-2034158Q8TAX9Espacenet
JP 2022524081 A2022-04-27137126Q8TAX9Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,184

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGSDMB papersNewest fiscal year
ZIAES049019Genetic And Environmental Factors In Childhood Respiratory and Allergic Illness92025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES82025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma62025
U19AI077439Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma62025
UH3OD023282Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-Up62025
P30CA016672Cancer Center Support Grant52025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital52025
P30ES006694Southwest Environmental Health Sciences Center52025
P30ES007048Environmental Exposures, Host Factors and Human Disease52025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes52025

1 to 10 of 1,184Source NIH's project files

See all 1,184 nih grants

Papers1,381

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-Ancestry Genome-wide Association Analyses Identify Shared and Specific Genetic Architecture in Mild and Moderate-to-Severe Asthma.medRxiv202642818167PubTator, text miningPubMed
Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese Women.Biomolecules202642793205PubTator, text miningPubMed
Unmasking programmed cell death in rhinovirus-driven asthma pathology.Biochem Soc Trans202642781720PubTator, text miningPubMed
Pyroptosis in chronic obstructive pulmonary disease: Beyond the canonical NLRP3/Caspase-1/GSDMD pathway.Immunol Res202642776308PubTator, text miningPubMed
Integrated bioinformatics analyses for GSDMB in carcinogenesis and progression of bladder cancer.Transl Androl Urol202642729139PubTator, text miningPubMed
Structural basis of GSDME pore formation and its regulation by S-palmitoylation.Proc Natl Acad Sci U S A202642636365PubTator, text miningPubMed
Downregulation of GSDMB by EBV-encoded miR-BART12-3p suppresses killer lymphocyte-mediated pyroptosis in gastric cancer cells.PLoS Pathog202642555663PubTator, text miningPubMed
GSDMB as a Therapeutic and Prognostic Target in Clear Cell Renal Cell Carcinoma: Insights From Pyroptosis-Related Gene Analysis.Front Biosci (Landmark Ed)202642530271PubTator, text miningPubMed
Cell Membrane-Modified Lipid Nanoparticle Enhanced Glioblastoma Immunotherapy via Metabolism Reprogramming and Pyroptosis Induction.Pharmaceutics202642514980PubTator, text miningPubMed
Disentangling Shared and Differential Genetic Architectures Between COVID-19 and Other Respiratory Disorders-A Genome-Wide Multi-Omics Framework.Int J Mol Sci202642511876PubTator, text miningPubMed

1 to 10 of 1,381

See all 1,381 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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