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Gene · 5588

PRKCQ: protein kinase C theta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRKCQ: protein kinase C theta. Genes, record 5588. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5588

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Gene

Symbol
PRKCQ
HGNC
Name
protein kinase C theta
HGNC
NCBI Gene ID
5588
NCBI Gene
HGNC ID
HGNC:9410
HGNC
Ensembl
ENSG00000065675
NCBI Gene
Aliases
PKCtheta, PKCθ, PRKCT, nPKC-theta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q04759Protein kinase C theta type7068Ensembl, GeneID, HGNC

Source UniProt

Patents91

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459731Q04759Espacenet
EP 4640849 A22025-10-29259Q04759Espacenet
EP 4641201 A22025-10-291740Q04759Espacenet
JP 2025524002 A2025-07-256Q04759Espacenet
JP 2025519096 A2025-06-24259Q04759Espacenet
JP 2025517969 A2025-06-121740Q04759Espacenet
KR 1020250039465 A2025-03-206Q04759Espacenet
JP 2025032204 A2025-03-1134066Q04759Espacenet
EP 4461818 A22024-11-1334066Q04759Espacenet
JP 2024023699 A2024-02-216Q04759Espacenet

1 to 10 of 91

See all 91 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEP-2563CHEMBL6069183Protein kinase C (PKC) inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Protein kinase C (PKC) inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Protein kinase C (PKC) inhibitorINHIBITORChEMBL
MIDOSTAURINCHEMBL608533Protein kinase C (PKC) inhibitorINHIBITORChEMBL
SOTRASTAURINCHEMBL565612Protein kinase C (PKC) inhibitorINHIBITORChEMBL
UCN-01CHEMBL574737Protein kinase C (PKC) inhibitorINHIBITORChEMBL

Trials71

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT06313437MIDOSTAURINPHASE1ClinicalTrials.gov
NCT05219266MIDOSTAURINClinicalTrials.gov
NCT04982354MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04496999MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04385290MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04174612MIDOSTAURINPHASE3ClinicalTrials.gov
NCT04097470MIDOSTAURINPHASE2ClinicalTrials.gov
NCT04075747MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04027309MIDOSTAURINPHASE3ClinicalTrials.gov

1 to 10 of 71

See all 71 trials

NIH grants1,481

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRKCQ papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30DK045735Yale Diabetes Research Center82025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies72025
P30CA008748Cancer Center Support Grant52025
P30CA076292Moffitt Cancer Center Support Grant52025
P30CA006973Regional Oncology Research Center42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
ZIABC011470Development of Natural Product Leads as Anticancer Therapeutics42025
P30CA014195Cancer Center Support Grant (CCSG)32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,481Source NIH's project files

See all 1,481 nih grants

Papers1,848

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Protein Kinase C-fused blue naevi with gene rearrangements involving PRKCD, PRKCQ, and PRKCG: expanding the genetic spectrum of an uncommon entity.Pathology202642827077PubTator, text miningPubMed
SUMOylation-Driven Subtype Heterogeneity and Prognostic Biomarkers in Renal Cell Carcinoma.Curr Issues Mol Biol202642651750PubTator, text miningPubMed
Identification and quantification of putative active constituents of huangqin decoction for ulcerative colitis treatment through the integration of chemical profiling, network pharmacology, and bioinformatics.
Front Chem202642602043PubTator, text miningPubMed
Integrative network pharmacology, transcriptomics, and molecular docking identify candidate Centella asiatica constituents and targets in neurodegenerative diseases.PLoS One202642536688PubTator, text miningPubMed
Uncovering Genetic Drivers of MASLD in South Asia: A Whole-Exome Sequencing Study in Pakistan.J Coll Physicians Surg Pak202642219829PubTator, text miningPubMed
PKCθ: from T cell kinase to immunometabolic integrator.Trends Pharmacol Sci202642103538PubTator, text miningPubMed
Identification of PANoptosis-related biomarkers in spinal cord injury (SCI) through multi-omics analysis and machine learning.Int J Neurosci202642037113PubTator, text miningPubMed
Protein kinase C theta: evolution, regulation, and function.Biochem J202641979916PubTator, text miningPubMed
Regulatory T cells in axial spondyloarthritis.Commun Biol202641917236PubTator, text miningPubMed
Associations of non-HLA gene polymorphisms with celiac disease in India.Sci Rep202641882060PubTator, text miningPubMed

1 to 10 of 1,848

See all 1,848 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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