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Gene · 5590

PRKCZ: protein kinase C zeta

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. PRKCZ: protein kinase C zeta. Genes, record 5590. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/5590

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
PRKCZ
HGNC
Name
protein kinase C zeta
HGNC
NCBI Gene ID
5590
NCBI Gene
HGNC ID
HGNC:9412
HGNC
Ensembl
ENSG00000067606
NCBI Gene
Aliases
PKC-ZETA, PKC2, PKCzeta, PKCζ
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q05513Protein kinase C zeta type5920Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2024123008 A2024-09-107859Q05513Espacenet
US 11892452 B22024-02-06152Q05513Espacenet
US 11708396 B22023-07-251881Q05513Espacenet
US 11446398 B22022-09-2068228Q05513Espacenet
JP 2022524081 A2022-04-27171199Q05513Espacenet
KR 1020220025810 A2022-03-032Q05513Espacenet
KR 1020210090594 A2021-07-2036Q05513Espacenet
US 11016093 B22021-05-25152Q05513Espacenet
US 10918740 B22021-02-168913Q05513Espacenet
US 10869935 B22020-12-228913Q05513Espacenet

1 to 10 of 38

See all 38 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEP-2563CHEMBL6069183Protein kinase C (PKC) inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Protein kinase C (PKC) inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Protein kinase C (PKC) inhibitorINHIBITORChEMBL
MIDOSTAURINCHEMBL608533Protein kinase C (PKC) inhibitorINHIBITORChEMBL
SOTRASTAURINCHEMBL565612Protein kinase C (PKC) inhibitorINHIBITORChEMBL
UCN-01CHEMBL574737Protein kinase C (PKC) inhibitorINHIBITORChEMBL

Trials71

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT06313437MIDOSTAURINPHASE1ClinicalTrials.gov
NCT05219266MIDOSTAURINClinicalTrials.gov
NCT04982354MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04496999MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04385290MIDOSTAURINPHASE1/PHASE2ClinicalTrials.gov
NCT04174612MIDOSTAURINPHASE3ClinicalTrials.gov
NCT04097470MIDOSTAURINPHASE2ClinicalTrials.gov
NCT04075747MIDOSTAURINPHASE1ClinicalTrials.gov
NCT04027309MIDOSTAURINPHASE3ClinicalTrials.gov

1 to 10 of 71

See all 71 trials

NIH grants3,149

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA016672Cancer Center Support Grant172025
P30DK020572Michigan Diabetes Research Center (MDRC)142025
P30CA030199Cancer Center Support Grant (CCSG)122025
P30CA008748Cancer Center Support Grant102025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)72025
P30CA016056Roswell Park Cancer Center Support Grant62025
R35GM122523Molecular Mechanisms of Cell Signaling62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant52025

1 to 10 of 3,149Source NIH's project files

See all 3,149 nih grants

Papers4,064

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42752668PubTator, text miningPubMed
42742991PubTator, text miningPubMed
42709486PubTator, text miningPubMed
42667124PubTator, text miningPubMed
42584835PubTator, text miningPubMed
42575166PubTator, text miningPubMed
42539170PubTator, text miningPubMed
42514310PubTator, text miningPubMed
42490363PubTator, text miningPubMed
42470583PubTator, text miningPubMed

1 to 10 of 4,064

See all 4,064 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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