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Gene · 55902

ACSS2: acyl-CoA synthetase short chain family member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACSS2: acyl-CoA synthetase short chain family member 2. Genes, record 55902. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55902

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Gene

Symbol
ACSS2
HGNC
Name
acyl-CoA synthetase short chain family member 2
HGNC
NCBI Gene ID
55902
NCBI Gene
HGNC ID
HGNC:15814
HGNC
Ensembl
ENSG00000131069
NCBI Gene
Aliases
ACAS2, ACECS, ACS, ACSA, AceCS, AceCS1, dJ1161H23.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NR19Acetyl-coenzyme A synthetase, cytoplasmic7010Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436343Q9NR19Espacenet
EP 4650780 A22025-11-197799Q9NR19Espacenet
EP 4641201 A22025-10-297883Q9NR19Espacenet
EP 4641202 A22025-10-29428Q9NR19Espacenet
JP 2025529142 A2025-09-04253Q9NR19Espacenet
US 12371689 B22025-07-29253Q9NR19Espacenet
JP 2025517969 A2025-06-127883Q9NR19Espacenet
JP 2025517970 A2025-06-127799Q9NR19Espacenet
US 12281084 B22025-04-222Q9NR19Espacenet
JP 2025062604 A2025-04-142044Q9NR19Espacenet

1 to 10 of 47

See all 47 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,317

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACSS2 papersNewest fiscal year
R01DK045343Regional Fatty Acid Metabolism In Humans142025
R01DK040484FFA Metabolism in Different Types of Human Obesity112025
P30CA008748Cancer Center Support Grant92025
P30CA010815Consolidated Basic Cancer Research Program92025
P30CA016672Cancer Center Support Grant82025
P30ES013508Center of Excellence in Environmental Toxicology72025
K12GM081259IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT).52025
I01BX000446Dynamic Regulation of Erythropoietin Gene Expression in Mammals.42025
P30CA068485Cancer Center Support Grant42025
P30DK019525University of Pennsylvania Diabetes Research Center42025

1 to 10 of 1,317Source NIH's project files

See all 1,317 nih grants

Papers1,833

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Highly expressed ACSF2 contributes to butyrate utilization in the rumen epithelium.J Nutr Biochem202742543122PubTator, text miningPubMed
From metabolic antagonism to homeostatic restoration: rewiring hepatic stellate cell bioenergetics for liver fibrosis reversal.Front Med (Lausanne)202642708043PubTator, text miningPubMed
ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH.Nat Commun202642649158PubTator, text miningPubMed
Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.Sci Adv202642647644PubTator, text miningPubMed
Dysregulated Acetate Metabolism and Cholesterol Biosynthesis in Cumulus Cells of Women with Polycystic Ovary Syndrome.Cell J202642634992PubTator, text miningPubMed
Acetate suppresses tumorigenesis through ACSS2-dependent H2A.Z acetylation in esophageal squamous cell carcinoma.Cell Rep202642632021PubTator, text miningPubMed
Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell Chem Biol202642586062PubTator, text miningPubMed
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis.Nat Cell Biol202642552361PubTator, text miningPubMed
ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment.iScience202642495523PubTator, text miningPubMed
Acetyl-CoA metabolism in skeletal biology and bone disorders: From mechanisms to therapeutic implications.Pharmacol Res202642468581PubTator, text miningPubMed

1 to 10 of 1,833

See all 1,833 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/55902

GET https://conductscience.org/api/genes/v1/55902/patents?page=2