Gene · 55902
ACSS2: acyl-CoA synthetase short chain family member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACSS2: acyl-CoA synthetase short chain family member 2. Genes, record 55902. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55902
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NR19 | Acetyl-coenzyme A synthetase, cytoplasmic | 701 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents47
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36343 | Q9NR19 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7799 | Q9NR19 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7883 | Q9NR19 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 428 | Q9NR19 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 253 | Q9NR19 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 253 | Q9NR19 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7883 | Q9NR19 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7799 | Q9NR19 | Espacenet |
| US 12281084 B2 | 2025-04-22 | 2 | Q9NR19 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 2044 | Q9NR19 | Espacenet |
1 to 10 of 47
See all 47 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,317
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACSS2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK045343 | Regional Fatty Acid Metabolism In Humans | 14 | 2025 |
| R01DK040484 | FFA Metabolism in Different Types of Human Obesity | 11 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 7 | 2025 |
| K12GM081259 | IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT). | 5 | 2025 |
| I01BX000446 | Dynamic Regulation of Erythropoietin Gene Expression in Mammals. | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 4 | 2025 |
1 to 10 of 1,317Source NIH's project files
See all 1,317 nih grantsPapers1,833
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Highly expressed ACSF2 contributes to butyrate utilization in the rumen epithelium. | J Nutr Biochem | 2027 | 42543122 | PubTator, text mining | PubMed |
| From metabolic antagonism to homeostatic restoration: rewiring hepatic stellate cell bioenergetics for liver fibrosis reversal. | Front Med (Lausanne) | 2026 | 42708043 | PubTator, text mining | PubMed |
| ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH. | Nat Commun | 2026 | 42649158 | PubTator, text mining | PubMed |
| Metabolic control of smooth muscle cell phenotype switching in atherosclerosis. | Sci Adv | 2026 | 42647644 | PubTator, text mining | PubMed |
| Dysregulated Acetate Metabolism and Cholesterol Biosynthesis in Cumulus Cells of Women with Polycystic Ovary Syndrome. | Cell J | 2026 | 42634992 | PubTator, text mining | PubMed |
| Acetate suppresses tumorigenesis through ACSS2-dependent H2A.Z acetylation in esophageal squamous cell carcinoma. | Cell Rep | 2026 | 42632021 | PubTator, text mining | PubMed |
| Beyond acetylation: Evaluating the emerging biology of lysine acylation. | Cell Chem Biol | 2026 | 42586062 | PubTator, text mining | PubMed |
| Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. | Nat Cell Biol | 2026 | 42552361 | PubTator, text mining | PubMed |
| ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment. | iScience | 2026 | 42495523 | PubTator, text mining | PubMed |
| Acetyl-CoA metabolism in skeletal biology and bone disorders: From mechanisms to therapeutic implications. | Pharmacol Res | 2026 | 42468581 | PubTator, text mining | PubMed |
1 to 10 of 1,833
See all 1,833 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/55902
GET https://conductscience.org/api/genes/v1/55902/patents?page=2