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PRKG1: protein kinase cGMP-dependent 1

1 protein, 32 patents, 0 drugs, 0 trials, 3,916 NIH grants and 6,417 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRKG1HGNC
Nameprotein kinase cGMP-dependent 1HGNC
NCBI Gene ID5592NCBI Gene
HGNC IDHGNC:9414HGNC
EnsemblENSG00000185532NCBI Gene
AliasesAAT8, PGK, PKG, PKG1, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13976cGMP-dependent protein kinase 167126Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459810Q13976Espacenet
EP 4650780 A22025-11-1911788Q13976Espacenet
EP 4641201 A22025-10-2912526Q13976Espacenet
JP 2025517969 A2025-06-1212526Q13976Espacenet
JP 2025517970 A2025-06-1211788Q13976Espacenet
JP 2025032204 A2025-03-1134074Q13976Espacenet
EP 4461818 A22024-11-1334074Q13976Espacenet
JP 2023058610 A2023-04-2534074Q13976Espacenet
US 11446398 B22022-09-2068388Q13976Espacenet
JP 2022524081 A2022-04-27171359Q13976Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3916

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32HL007227Pathophysiology of Myocardial Disease212,025NIH's project files
P30CA056036Translational Research in Cancer92,025NIH's project files
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal82,025NIH's project files
P30CA016672Cancer Center Support Grant72,025NIH's project files
P30CA068485Cancer Center Support Grant72,025NIH's project files
R01HL060190Metabolic reprogramming of smooth muscle cells in pulmonary hypertension72,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files
P30CA008748Cancer Center Support Grant62,025NIH's project files
R01HL132141A novel treatment of aortic disease in Marfan Syndrome targeting oxidative stress and PKG dysregulation62,025NIH's project files

Papers 6417

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819776PubTator, text miningPubMed
42781371PubTator, text miningPubMed
42774473PubTator, text miningPubMed
42744925PubTator, text miningPubMed
42743238PubTator, text miningPubMed
42729125PubTator, text miningPubMed
42685200PubTator, text miningPubMed
42647240PubTator, text miningPubMed
42644613PubTator, text miningPubMed
42638569PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license