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MAPK1: mitogen-activated protein kinase 1

1 protein, 236 patents, 6 drugs, 25 trials, 38,003 NIH grants and 149,001 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMAPK1HGNC
Namemitogen-activated protein kinase 1HGNC
NCBI Gene ID5594NCBI Gene
HGNC IDHGNC:6871HGNC
EnsemblENSG00000100030NCBI Gene
AliasesERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P28482Mitogen-activated protein kinase 1360160Ensembl, GeneID, HGNCUniProt

Patents 236

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19284P28482Espacenet
EP 4623996 A22025-10-018P28482Espacenet
WO 2025177214 A12025-08-2812P28482Espacenet
JP 2025118759 A2025-08-135P28482Espacenet
JP 2025517970 A2025-06-12284P28482Espacenet
JP 2025509296 A2025-04-11129P28482Espacenet
JP 2025509296 A2025-04-11130P28482Espacenet
US 12252709 B22025-03-189P28482Espacenet
US 12252709 B22025-03-1810P28482Espacenet
EP 4490268 A12025-01-15129P28482Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASN007CHEMBL4650280Mitogen-activated protein kinase; ERK1/ERK2 inhibitorINHIBITORChEMBL
KO-947CHEMBL4650284Mitogen-activated protein kinase; ERK1/ERK2 inhibitorINHIBITORChEMBL
MK-8353CHEMBL4213970MAP kinase ERK2 inhibitorINHIBITORChEMBL
RAVOXERTINIBCHEMBL3544964MAP kinase ERK2 inhibitorINHIBITORChEMBL
TEMUTERKIBCHEMBL4650285Mitogen-activated protein kinase; ERK1/ERK2 inhibitorINHIBITORChEMBL
ULIXERTINIBCHEMBL3590106MAP kinase ERK2 inhibitorINHIBITORChEMBL

Trials 25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06773195ULIXERTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT06411821ULIXERTINIBPHASE2ClinicalTrials.gov
NCT06400225ULIXERTINIBPHASE2ClinicalTrials.gov
NCT05985954ULIXERTINIBPHASE1ClinicalTrials.gov
NCT05804227ULIXERTINIBEARLY_PHASE1ClinicalTrials.gov
NCT05221320ULIXERTINIBPHASE22025-09-25ClinicalTrials.gov
NCT04916236TEMUTERKIBPHASE1ClinicalTrials.gov
NCT04616183TEMUTERKIBPHASE1/PHASE2ClinicalTrials.gov
NCT04566393ULIXERTINIBClinicalTrials.gov
NCT04534283TEMUTERKIBPHASE22024-08-07ClinicalTrials.gov

NIH grants 38003

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant8122,025NIH's project files
P30CA008748Cancer Center Support Grant5292,025NIH's project files
P30CA016058Cancer Center Support Grant1642,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant1382,025NIH's project files
P30CA068485Cancer Center Support Grant1252,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant1252,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1022,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase982,025NIH's project files
P30CA006973Regional Oncology Research Center972,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program962,025NIH's project files

Papers 149001

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42826809PubTator, text miningPubMed
42825856PubTator, text miningPubMed
42824304PubTator, text miningPubMed
42823178PubTator, text miningPubMed
42822143PubTator, text miningPubMed
42821479PubTator, text miningPubMed
42820076PubTator, text miningPubMed
42818132PubTator, text miningPubMed
42817838PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license