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MAPK3: mitogen-activated protein kinase 3

1 protein, 127 patents, 6 drugs, 25 trials, 16,414 NIH grants and 45,884 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMAPK3HGNC
Namemitogen-activated protein kinase 3HGNC
NCBI Gene ID5595NCBI Gene
HGNC IDHGNC:6877HGNC
EnsemblENSG00000102882NCBI Gene
AliasesERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, p44erk1, p44mapkNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P27361Mitogen-activated protein kinase 33798Ensembl, GeneID, HGNCUniProt

Patents 127

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026000906 A2026-01-06156P27361Espacenet
EP 4650780 A22025-11-192151P27361Espacenet
WO 2025177214 A12025-08-2813P27361Espacenet
JP 2025118759 A2025-08-133P27361Espacenet
JP 2025517970 A2025-06-122151P27361Espacenet
JP 2025509296 A2025-04-11125P27361Espacenet
US 12252709 B22025-03-185P27361Espacenet
EP 4490268 A12025-01-15125P27361Espacenet
US 12150938 B22024-11-2612P27361Espacenet
JP 2024123008 A2024-09-107045P27361Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASN007CHEMBL4650280Mitogen-activated protein kinase; ERK1/ERK2 inhibitorINHIBITORChEMBL
KO-947CHEMBL4650284Mitogen-activated protein kinase; ERK1/ERK2 inhibitorINHIBITORChEMBL
MK-8353CHEMBL4213970MAP kinase ERK1 inhibitorINHIBITORChEMBL
RAVOXERTINIBCHEMBL3544964MAP kinase ERK1 inhibitorINHIBITORChEMBL
TEMUTERKIBCHEMBL4650285Mitogen-activated protein kinase; ERK1/ERK2 inhibitorINHIBITORChEMBL
ULIXERTINIBCHEMBL3590106MAP kinase ERK1 inhibitorINHIBITORChEMBL

Trials 25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06773195ULIXERTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT06411821ULIXERTINIBPHASE2ClinicalTrials.gov
NCT06400225ULIXERTINIBPHASE2ClinicalTrials.gov
NCT05985954ULIXERTINIBPHASE1ClinicalTrials.gov
NCT05804227ULIXERTINIBEARLY_PHASE1ClinicalTrials.gov
NCT05221320ULIXERTINIBPHASE22025-09-25ClinicalTrials.gov
NCT04916236TEMUTERKIBPHASE1ClinicalTrials.gov
NCT04616183TEMUTERKIBPHASE1/PHASE2ClinicalTrials.gov
NCT04566393ULIXERTINIBClinicalTrials.gov
NCT04534283TEMUTERKIBPHASE22024-08-07ClinicalTrials.gov

NIH grants 16414

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1682,025NIH's project files
P30CA008748Cancer Center Support Grant682,025NIH's project files
P30CA068485Cancer Center Support Grant402,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant382,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant352,025NIH's project files
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors332,025NIH's project files
P30CA016058Cancer Center Support Grant322,025NIH's project files
P30CA056036Translational Research in Cancer292,025NIH's project files
P30CA016087Cancer Center Support Grant282,025NIH's project files
P30CA016086Cancer Center Support Grant262,025NIH's project files

Papers 45884

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42812104PubTator, text miningPubMed
42808714PubTator, text miningPubMed
42805099PubTator, text miningPubMed
42801250PubTator, text miningPubMed
42793267PubTator, text miningPubMed
42780846PubTator, text miningPubMed
42775789PubTator, text miningPubMed
42772652PubTator, text miningPubMed
42772019PubTator, text miningPubMed
42769509PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license