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Gene · 5598

MAPK7: mitogen-activated protein kinase 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAPK7: mitogen-activated protein kinase 7. Genes, record 5598. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5598

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Gene

Symbol
MAPK7
HGNC
Name
mitogen-activated protein kinase 7
HGNC
NCBI Gene ID
5598
NCBI Gene
HGNC ID
HGNC:6880
HGNC
Ensembl
ENSG00000166484
NCBI Gene
Aliases
BMK1, ERK4, ERK5, PRKM7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13164Mitogen-activated protein kinase 781614Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453938Q13164Espacenet
JP 2026004568 A2026-01-1453939Q13164Espacenet
JP 2026004568 A2026-01-1453940Q13164Espacenet
WO 2025262045 A12025-12-2617Q13164Espacenet
EP 4650780 A22025-11-194725Q13164Espacenet
EP 4641201 A22025-10-294296Q13164Espacenet
JP 2025517969 A2025-06-124296Q13164Espacenet
JP 2025517970 A2025-06-124725Q13164Espacenet
EP 4518908 A22025-03-1211Q13164Espacenet
JP 2024112982 A2024-08-214377Q13164Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,298

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAPK7 papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant112025
R01GM048533Intracellular Stress Inputs to SAPK Signaling Pathways72025
T32CA009138Molecular, Genetic and Cellular Targets of Cancer Training Program72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA016086Cancer Center Support Grant62025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA013148Comprehensive Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025

1 to 10 of 2,298Source NIH's project files

See all 2,298 nih grants

Papers3,971

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Loss of Smad4 drives vascular malformations via c-KIT-dependent high-fluid shear stress mimicry.J Clin Invest202642820305PubTator, text miningPubMed
Retraction notice to "Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways" [Int. Immunopharmacol. 140 (2024) 112777].
Int Immunopharmacol202642760158PubTator, text miningPubMed
Network based approach identifies miR-145-3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma.J Pathol202642713718PubTator, text miningPubMed
Berberine Attenuates Hypertrophic Phenotype in RAF1-Mutant Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Suppression of ERK5-Cyclin D1 Signaling.Cardiovasc Drugs Ther202642667574PubTator, text miningPubMed
Correction to: Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner.Protein Cell202642607144PubTator, text miningPubMed
Targeting ferroptosis through kinase signaling: The roles of MAPK and AMPK pathways in cancer therapy.Eur J Cell Biol202642600414PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
miR-506-5p targets MAPK7 to impede glioma growth and invasion through suppressing epithelial-mesenchymal transition and matrix metalloproteinases.Transl Cancer Res202642591582PubTator, text miningPubMed
In Vitro Modelling of Obstructive Sleep Apnea by Intermittent Hypoxia of Human Embryonic Stem Cell-Derived Cardiomyocytes: Expression of ERK1/2, ERK5 and Erbin.Int J Mol Sci202642589461PubTator, text miningPubMed
[Study on Huanglian Jiedu Decoction improving ox-LDL-induced LC3-related phagocytosis dysfunction in RAW264.7 macrophages by activating ERK5].Zhongguo Zhong Yao Za Zhi202642543371PubTator, text miningPubMed

1 to 10 of 3,971

See all 3,971 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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