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MAP2K1: mitogen-activated protein kinase kinase 1

1 protein, 132 patents, 21 drugs, 607 trials, 7,713 NIH grants and 15,688 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMAP2K1HGNC
Namemitogen-activated protein kinase kinase 1HGNC
NCBI Gene ID5604NCBI Gene
HGNC IDHGNC:6840HGNC
EnsemblENSG00000169032NCBI Gene
AliasesCFC3, MAPKK1, MEK1, MEL, MKK1, PRKMK1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q02750Dual specificity mitogen-activated protein kinase kinase 139394Ensembl, GeneID, HGNCUniProt

Patents 132

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026053745 A2026-03-2564Q02750Espacenet
JP 2026053745 A2026-03-2578Q02750Espacenet
EP 4653055 A22025-11-2664Q02750Espacenet
EP 4653055 A22025-11-2678Q02750Espacenet
EP 4650780 A22025-11-194142Q02750Espacenet
JP 2025517970 A2025-06-124142Q02750Espacenet
EP 4484957 A12025-01-0185Q02750Espacenet
US 12150938 B22024-11-269Q02750Espacenet
US 12130292 B22024-10-2913Q02750Espacenet
JP 2024133638 A2024-10-0264Q02750Espacenet

Drugs 21

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AS-703988CHEMBL3545243Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
AVUTOMETINIBCHEMBL3264002Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
AZD-8330CHEMBL3182621Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
BALAMAPIMODCHEMBL2104954Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
BINIMETINIBCHEMBL3187723Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
CI-1040CHEMBL105442Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
COBIMETINIBCHEMBL2146883Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
COBIMETINIB FUMARATECHEMBL2364607Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
E-6201CHEMBL1097999Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL
MIRDAMETINIBCHEMBL507361Dual specificity mitogen-activated protein kinase kinase 1 inhibitorINHIBITORChEMBL

Trials 607

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07549646TRAMETINIBPHASE2ClinicalTrials.gov
NCT07539441MIRDAMETINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07521657MIRDAMETINIBPHASE2ClinicalTrials.gov
NCT07477457TRAMETINIBPHASE2ClinicalTrials.gov
NCT07449754COBIMETINIBPHASE2ClinicalTrials.gov
NCT07419932TRAMETINIBClinicalTrials.gov
NCT07318324AVUTOMETINIBPHASE1ClinicalTrials.gov
NCT07237100MIRDAMETINIBPHASE2ClinicalTrials.gov
NCT07126158AVUTOMETINIBPHASE2ClinicalTrials.gov
NCT07110246TRAMETINIBPHASE2ClinicalTrials.gov

NIH grants 7713

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2392,025NIH's project files
P30CA016672Cancer Center Support Grant1952,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase382,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant372,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant282,025NIH's project files
P30CA068485Cancer Center Support Grant272,025NIH's project files
P30CA016058Cancer Center Support Grant252,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program232,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award222,025NIH's project files
P30CA016086Cancer Center Support Grant202,025NIH's project files

Papers 15688

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42809935PubTator, text miningPubMed
42805099PubTator, text miningPubMed
42792557PubTator, text miningPubMed
42780127PubTator, text miningPubMed
42769443PubTator, text miningPubMed
42759115PubTator, text miningPubMed
42758816PubTator, text miningPubMed
42750542PubTator, text miningPubMed
42720827PubTator, text miningPubMed
42710135PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license