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MAP2K2: mitogen-activated protein kinase kinase 2

1 protein, 102 patents, 20 drugs, 603 trials, 3,981 NIH grants and 7,320 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMAP2K2HGNC
Namemitogen-activated protein kinase kinase 2HGNC
NCBI Gene ID5605NCBI Gene
HGNC IDHGNC:6842HGNC
EnsemblENSG00000126934NCBI Gene
AliasesCFC4, MAPKK2, MEK2, MKK2, PRKMK2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P36507Dual specificity mitogen-activated protein kinase kinase 24002Ensembl, GeneID, HGNCUniProt

Patents 102

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192141P36507Espacenet
JP 2025517970 A2025-06-122141P36507Espacenet
US 12130292 B22024-10-2914P36507Espacenet
JP 2024123008 A2024-09-107062P36507Espacenet
EP 4384828 A12024-06-1929P36507Espacenet
US 11708396 B22023-07-251780P36507Espacenet
US 11446398 B22022-09-2052471P36507Espacenet
JP 2022524081 A2022-04-27155442P36507Espacenet
US 11306146 B22022-04-1917P36507Espacenet
US 11237173 B22022-02-0114P36507Espacenet

Drugs 20

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AS-703988CHEMBL3545243Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
AVUTOMETINIBCHEMBL3264002Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
AZD-8330CHEMBL3182621Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
BALAMAPIMODCHEMBL2104954Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
BINIMETINIBCHEMBL3187723Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
CI-1040CHEMBL105442Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
COBIMETINIBCHEMBL2146883Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
COBIMETINIB FUMARATECHEMBL2364607Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
MIRDAMETINIBCHEMBL507361Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL
PIMASERTIBCHEMBL2107832Dual specificity mitogen-activated protein kinase kinase 2 inhibitorINHIBITORChEMBL

Trials 603

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07549646TRAMETINIBPHASE2ClinicalTrials.gov
NCT07539441MIRDAMETINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07521657MIRDAMETINIBPHASE2ClinicalTrials.gov
NCT07477457TRAMETINIBPHASE2ClinicalTrials.gov
NCT07449754COBIMETINIBPHASE2ClinicalTrials.gov
NCT07419932TRAMETINIBClinicalTrials.gov
NCT07318324AVUTOMETINIBPHASE1ClinicalTrials.gov
NCT07237100MIRDAMETINIBPHASE2ClinicalTrials.gov
NCT07126158AVUTOMETINIBPHASE2ClinicalTrials.gov
NCT07110246TRAMETINIBPHASE2ClinicalTrials.gov

NIH grants 3981

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant902,025NIH's project files
P30CA008748Cancer Center Support Grant732,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant252,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase162,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant162,025NIH's project files
P30CA016086Cancer Center Support Grant152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program122,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)112,025NIH's project files
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment92,025NIH's project files

Papers 7320

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820356PubTator, text miningPubMed
42764186PubTator, text miningPubMed
42507094PubTator, text miningPubMed
42450323PubTator, text miningPubMed
42450261PubTator, text miningPubMed
42434223PubTator, text miningPubMed
42353095PubTator, text miningPubMed
42342966PubTator, text miningPubMed
42312723PubTator, text miningPubMed
42274072PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license