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Gene · 5606

MAP2K3: mitogen-activated protein kinase kinase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAP2K3: mitogen-activated protein kinase kinase 3. Genes, record 5606. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5606

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Gene

Symbol
MAP2K3
HGNC
Name
mitogen-activated protein kinase kinase 3
HGNC
NCBI Gene ID
5606
NCBI Gene
HGNC ID
HGNC:6843
HGNC
Ensembl
ENSG00000034152
NCBI Gene
Aliases
MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46734Dual specificity mitogen-activated protein kinase kinase 33470Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196945P46734Espacenet
JP 2025517970 A2025-06-126945P46734Espacenet
JP 2024123008 A2024-09-107064P46734Espacenet
JP 2024507735 A2024-02-21144P46734Espacenet
US 11446398 B22022-09-2052475P46734Espacenet
JP 2022524081 A2022-04-27155446P46734Espacenet
US 10918740 B22021-02-168983P46734Espacenet
US 10869935 B22020-12-228983P46734Espacenet
WO 2020043864 A12020-03-051498P46734Espacenet
US 10501513 B22019-12-107064P46734Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,840

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP2K3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT62025
P30CA138292Winship Cancer Institute Cancer Center Support Grant62025
ZIADK069028Genetic Epidemiology of Diabetes and Obesity62025
P30CA008748Cancer Center Support Grant52025
P30AG021342Claude D. Pepper Older Americans Independence Center at Yale42025
P30CA068485Cancer Center Support Grant42025
ZIADK069071Structural Analysis Of Candidate Genes For Type 2 Diabetes and Obesity42025
ZIADK075012Follow-Up Studies of a Genome-Wide Association Analysis in Pima Indians42025
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center32025

1 to 10 of 1,840Source NIH's project files

See all 1,840 nih grants

Papers2,515

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Network toxicology, transcriptomics, immune infiltration, and machine learning-based construction of an environmental endocrine disruptor exposure-associated predictive model for osteonecrosis of the femoral head.
Comput Biol Chem202642767134PubTator, text miningPubMed
Atypical p38 kinase signaling and pathological impact on human health.Biochem J202642621771PubTator, text miningPubMed
Genome-wide association study of egg numbers across different laying phases in a large-scale layer population.Br Poult Sci202642615881PubTator, text miningPubMed
Targeting GEM Reprograms Macrophages and Overcomes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma.Cancer Res202642561099PubTator, text miningPubMed
Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes.Front Endocrinol (Lausanne)202642460311PubTator, text miningPubMed
Small Molecule Activators of Antitumor Immunity.Acc Chem Res202642342561PubTator, text miningPubMed
P2Y12-AMPKα2 signaling contributes to cardiomyocyte senescence in doxorubicin-induced heart failure.Mol Cell Biochem202642340549PubTator, text miningPubMed
THBS1 reverses sevoflurane-mediated apoptosis and invasion suppression in glioblastoma: An oxidative stress-related gene signature for prognosis and predicting immunotherapy response.J Neuroimmunol202642217519PubTator, text miningPubMed
PRKN Ser131 phosphorylation promotes cigarette smoke-induced mitophagy impairment and epithelial cell senescence via MKK3/p38 MAPK activation: An in vitro and in vivo study.Tob Induc Dis202642212306PubTator, text miningPubMed
Proteomic and experimental analyses reveal molecular signatures of flexural atopic dermatitis in antecubital and popliteal fossae and the therapeutic effect of Aida lotion.Front Immunol202641988190PubTator, text miningPubMed

1 to 10 of 2,515

See all 2,515 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5606

GET https://conductscience.org/api/genes/v1/5606/patents?page=2