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Gene · 5607

MAP2K5: mitogen-activated protein kinase kinase 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAP2K5: mitogen-activated protein kinase kinase 5. Genes, record 5607. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5607

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Gene

Symbol
MAP2K5
HGNC
Name
mitogen-activated protein kinase kinase 5
HGNC
NCBI Gene ID
5607
NCBI Gene
HGNC ID
HGNC:6845
HGNC
Ensembl
ENSG00000137764
NCBI Gene
Aliases
HsT17454, MAPKK5, MEK5, PRKMK5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13163Dual specificity mitogen-activated protein kinase kinase 54483Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453957Q13163Espacenet
WO 2025262045 A12025-12-2615Q13163Espacenet
EP 4641201 A22025-10-29128Q13163Espacenet
JP 2025517969 A2025-06-12128Q13163Espacenet
KR 1020250036258 A2025-03-1328Q13163Espacenet
US 11446398 B22022-09-2052495Q13163Espacenet
JP 2022524081 A2022-04-27155466Q13163Espacenet
JP 2022513928 A2022-02-0928Q13163Espacenet
KR 1020210104073 A2021-08-2428Q13163Espacenet
JP 2019054813 A2019-04-11234392Q13163Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,410

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP2K5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30DK063491Diabetes Research Center (DRC)82025
P2CHD050924Carolina Population Center72025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
T32HL007055Cardiovascular Epidemiology Training Grant62025
P30CA008748Cancer Center Support Grant52025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52025
P30CA016086Cancer Center Support Grant42025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025

1 to 10 of 1,410Source NIH's project files

See all 1,410 nih grants

Papers1,405

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Circadian-Melatonin Axis in Bone Remodeling: Receptor-Dependent Signaling, Receptor-Independent Actions, and Translational Constraints.Biomolecules202642793064PubTator, text miningPubMed
Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism.bioRxiv202642779987PubTator, text miningPubMed
Berberine Attenuates Hypertrophic Phenotype in RAF1-Mutant Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Suppression of ERK5-Cyclin D1 Signaling.Cardiovasc Drugs Ther202642667574PubTator, text miningPubMed
Educational attainment and diabetes risk: triangulation evidence from UK Biobank prospective cohort, NHANES 2011-2018, and cross-trait genomics analyses.Front Endocrinol (Lausanne)202642434303PubTator, text miningPubMed
Compound Danshen Dripping Pills retards the progression of cerebral cavernous malformations via strengthening vascular integrity and ameliorating inflammatory response.Phytomedicine202642341528PubTator, text miningPubMed
Integration of Brain Proteomes and Genome-Wide Association Data Identifies GLO1 as a Candidate Causal Gene and Therapeutic Target for Restless Legs Syndrome.Int J Mol Sci202642196425PubTator, text miningPubMed
A systematic review on the impact of type 2 diabetes on Leydig and Sertoli cells: Molecular mechanisms and functional consequences.Diabetes Metab Syndr202642097114PubTator, text miningPubMed
Molecular and Cellular Mechanisms of Anti-Obesity Agents: An Integrative Review.FASEB J202642036909PubTator, text miningPubMed
Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma.Signal Transduct Target Ther202641946693PubTator, text miningPubMed
AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma.Neoplasia202641916083PubTator, text miningPubMed

1 to 10 of 1,405

See all 1,405 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5607

GET https://conductscience.org/api/genes/v1/5607/patents?page=2