Gene · 5607
MAP2K5: mitogen-activated protein kinase kinase 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAP2K5: mitogen-activated protein kinase kinase 5. Genes, record 5607. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5607
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13163 | Dual specificity mitogen-activated protein kinase kinase 5 | 448 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 53957 | Q13163 | Espacenet |
| WO 2025262045 A1 | 2025-12-26 | 15 | Q13163 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 128 | Q13163 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 128 | Q13163 | Espacenet |
| KR 1020250036258 A | 2025-03-13 | 28 | Q13163 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52495 | Q13163 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 155466 | Q13163 | Espacenet |
| JP 2022513928 A | 2022-02-09 | 28 | Q13163 | Espacenet |
| KR 1020210104073 A | 2021-08-24 | 28 | Q13163 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 234392 | Q13163 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,410
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAP2K5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 8 | 2025 |
| P2CHD050924 | Carolina Population Center | 7 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 6 | 2025 |
| T32HL007055 | Cardiovascular Epidemiology Training Grant | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 5 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
1 to 10 of 1,410Source NIH's project files
See all 1,410 nih grantsPapers1,405
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The Circadian-Melatonin Axis in Bone Remodeling: Receptor-Dependent Signaling, Receptor-Independent Actions, and Translational Constraints. | Biomolecules | 2026 | 42793064 | PubTator, text mining | PubMed |
| Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism. | bioRxiv | 2026 | 42779987 | PubTator, text mining | PubMed |
| Berberine Attenuates Hypertrophic Phenotype in RAF1-Mutant Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Suppression of ERK5-Cyclin D1 Signaling. | Cardiovasc Drugs Ther | 2026 | 42667574 | PubTator, text mining | PubMed |
| Educational attainment and diabetes risk: triangulation evidence from UK Biobank prospective cohort, NHANES 2011-2018, and cross-trait genomics analyses. | Front Endocrinol (Lausanne) | 2026 | 42434303 | PubTator, text mining | PubMed |
| Compound Danshen Dripping Pills retards the progression of cerebral cavernous malformations via strengthening vascular integrity and ameliorating inflammatory response. | Phytomedicine | 2026 | 42341528 | PubTator, text mining | PubMed |
| Integration of Brain Proteomes and Genome-Wide Association Data Identifies GLO1 as a Candidate Causal Gene and Therapeutic Target for Restless Legs Syndrome. | Int J Mol Sci | 2026 | 42196425 | PubTator, text mining | PubMed |
| A systematic review on the impact of type 2 diabetes on Leydig and Sertoli cells: Molecular mechanisms and functional consequences. | Diabetes Metab Syndr | 2026 | 42097114 | PubTator, text mining | PubMed |
| Molecular and Cellular Mechanisms of Anti-Obesity Agents: An Integrative Review. | FASEB J | 2026 | 42036909 | PubTator, text mining | PubMed |
| Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma. | Signal Transduct Target Ther | 2026 | 41946693 | PubTator, text mining | PubMed |
| AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma. | Neoplasia | 2026 | 41916083 | PubTator, text mining | PubMed |
1 to 10 of 1,405
See all 1,405 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5607
GET https://conductscience.org/api/genes/v1/5607/patents?page=2