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MAP2K6: mitogen-activated protein kinase kinase 6
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Gene · 5608

Papers2,492

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,492

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TitleJournalYearPMIDFound bySource
DONSON links tumor-cell survival to MIF-associated macrophage remodeling in small cell lung cancer.Apoptosis202642791421PubTator, text miningPubMed
Punicic acid alleviates osteoarthritis progression through miR-29a-3p-dependent inhibition of the MAP2K6/p38 MAPK pathway.In Vitro Cell Dev Biol Anim202642747754PubTator, text miningPubMed
Atypical p38 kinase signaling and pathological impact on human health.Biochem J202642621771PubTator, text miningPubMed
[Correlation analysis of MAP2K6 expression in nasopharyngeal carcinoma tissues with EBV infection and clinical prognosis].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi202642576641PubTator, text miningPubMed
GPR143 mediates virus-induced cytoplasmic vacuolation through the MKK6-p38 pathway in teleosts.Zool Res202642533577PubTator, text miningPubMed
MAP2K6 reprograms NAD+ metabolism via the HMGA1-NAMPT axis to sensitize ovarian cancer cells to PARP inhibition.Cell Death Dis202642469197PubTator, text miningPubMed
APOA1, DEFB103A_DEFB103B and DSG3 Are Novel Circulating Biomarkers of Psoriasis.Int J Mol Sci202642450078PubTator, text miningPubMed
Proteomic and transcriptomic analyses identify the role of RBM25 in the malignant progression of glioma.Int J Neurosci202642216302PubTator, text miningPubMed
The immune dysregulation landscape and dynamic regulation of competing endogenous RNAs in spinal cord injury.Front Immunol202642183235PubTator, text miningPubMed
Single-Cell Analysis of Human Heart Failure With Preserved Ejection Fraction.Circ Res202642137938PubTator, text miningPubMed
Serum proteomic changes in atopic dermatitis patients treated with cyclosporine.PLoS One202642008513PubTator, text miningPubMed
MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity.Cell Rep202641886451PubTator, text miningPubMed
Doxorubicin induces ferroptosis in endometrial cancer by suppressing the MKK6/p38/CEBPB axis.J Transl Med202641840703PubTator, text miningPubMed
A Novel Wogonin Derivative Induces Apoptosis in PC-3M Cells by Targeting Mitochondrial Dysfunction and Activating the ROS-p38/MAPK Pathway.Molecules202641828845PubTator, text miningPubMed
Single-Cell Transcriptomic Profile Associated with Sub-Subtype A6 and CRF63-02A6 HIV-1 Strain Infection.Viruses202641754547PubTator, text miningPubMed
Targeting the JNK Gatekeepers: Structural Evolution and Medicinal Chemistry of MKK4 and MKK7 Inhibitors.Molecules202641752451PubTator, text miningPubMed
Multi-cohort and single-cell profiling of aging genes reveals prognostic and therapeutic targets in breast cancer.iScience202641732271PubTator, text miningPubMed
Proteomic Insights into Heroin Use: Links to Neurodegeneration.Mol Neurobiol202641721130PubTator, text miningPubMed
microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2.Mol Ther Nucleic Acids202641717286PubTator, text miningPubMed
Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth-Associated Proteins.Aging Cell202641655127PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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