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Gene · 5608

MAP2K6: mitogen-activated protein kinase kinase 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAP2K6: mitogen-activated protein kinase kinase 6. Genes, record 5608. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5608

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Gene

Symbol
MAP2K6
HGNC
Name
mitogen-activated protein kinase kinase 6
HGNC
NCBI Gene ID
5608
NCBI Gene
HGNC ID
HGNC:6846
HGNC
Ensembl
ENSG00000108984
NCBI Gene
Aliases
CRCMSL, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P52564Dual specificity mitogen-activated protein kinase kinase 63349Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453961P52564Espacenet
JP 2026004568 A2026-01-1453962P52564Espacenet
EP 4641202 A22025-10-299130P52564Espacenet
JP 2025032204 A2025-03-1131171P52564Espacenet
KR 1020250017231 A2025-02-049130P52564Espacenet
EP 4461818 A22024-11-1331171P52564Espacenet
JP 2023058610 A2023-04-2531171P52564Espacenet
US 11446398 B22022-09-2052506P52564Espacenet
JP 2022524081 A2022-04-27155477P52564Espacenet
KR 1020210135184 A2021-11-125P52564Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,919

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP2K6 papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
R01CA109182Functional Determinants of Metastatic Dormancy52025
P30CA008748Cancer Center Support Grant42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30CA068485Cancer Center Support Grant42025
P30ES006694Southwest Environmental Health Sciences Center42025
P42ES004940The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation42025
R01GM086858New Molecular Probes For Protein Kinases42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30AG021342Claude D. Pepper Older Americans Independence Center at Yale32025

1 to 10 of 1,919Source NIH's project files

See all 1,919 nih grants

Papers2,492

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DONSON links tumor-cell survival to MIF-associated macrophage remodeling in small cell lung cancer.Apoptosis202642791421PubTator, text miningPubMed
Punicic acid alleviates osteoarthritis progression through miR-29a-3p-dependent inhibition of the MAP2K6/p38 MAPK pathway.In Vitro Cell Dev Biol Anim202642747754PubTator, text miningPubMed
Atypical p38 kinase signaling and pathological impact on human health.Biochem J202642621771PubTator, text miningPubMed
[Correlation analysis of MAP2K6 expression in nasopharyngeal carcinoma tissues with EBV infection and clinical prognosis].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi202642576641PubTator, text miningPubMed
GPR143 mediates virus-induced cytoplasmic vacuolation through the MKK6-p38 pathway in teleosts.Zool Res202642533577PubTator, text miningPubMed
MAP2K6 reprograms NAD+ metabolism via the HMGA1-NAMPT axis to sensitize ovarian cancer cells to PARP inhibition.Cell Death Dis202642469197PubTator, text miningPubMed
APOA1, DEFB103A_DEFB103B and DSG3 Are Novel Circulating Biomarkers of Psoriasis.Int J Mol Sci202642450078PubTator, text miningPubMed
Proteomic and transcriptomic analyses identify the role of RBM25 in the malignant progression of glioma.Int J Neurosci202642216302PubTator, text miningPubMed
The immune dysregulation landscape and dynamic regulation of competing endogenous RNAs in spinal cord injury.Front Immunol202642183235PubTator, text miningPubMed
Single-Cell Analysis of Human Heart Failure With Preserved Ejection Fraction.Circ Res202642137938PubTator, text miningPubMed

1 to 10 of 2,492

See all 2,492 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5608

GET https://conductscience.org/api/genes/v1/5608/patents?page=2