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EIF2AK2: eukaryotic translation initiation factor 2 alpha kinase 2

1 protein, 95 patents, 0 drugs, 0 trials, 5,749 NIH grants and 10,621 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEIF2AK2HGNC
Nameeukaryotic translation initiation factor 2 alpha kinase 2HGNC
NCBI Gene ID5610NCBI Gene
HGNC IDHGNC:9437HGNC
EnsemblENSG00000055332NCBI Gene
AliasesPKR, PPP1R83, PRKRNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P19525Interferon-induced, double-stranded RNA-activated protein kinase55112Ensembl, GeneID, HGNCUniProt

Patents 95

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2024123008 A2024-09-106074P19525Espacenet
JP 2024123008 A2024-09-106077P19525Espacenet
US 12006548 B22024-06-11440P19525Espacenet
US 11884978 B22024-01-30496P19525Espacenet
US 11873486 B22024-01-1631P19525Espacenet
JP 2023064788 A2023-05-12123P19525Espacenet
WO 2023074711 A2023-05-0446P19525Espacenet
US 11446398 B22022-09-2028638P19525Espacenet
US 11446398 B22022-09-2028640P19525Espacenet
US 11408034 B22022-08-09391P19525Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5749

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant352,025NIH's project files
ZIAHD001010Mechanism and Regulation of Eukaryotic Protein Synthesis182,025NIH's project files
R01AI080607Studies in Poxvirus Host Range Genes and Tropism172,025NIH's project files
P01CA013106Targeting Transcription and Splicing in Cancer162,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase162,025NIH's project files
R01AI140442Betacoronaviruses: activation and antagonism of host innate immune responses142,025NIH's project files
P01CA163205Circumventing Barriers to Effective Oncolytic Virotherapy of Malignant Gliomas122,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
P30CA015704Cancer Center Support Grant122,025NIH's project files
P30CA091842Cancer Center Support Grant122,025NIH's project files

Papers 10621

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825516PubTator, text miningPubMed
42814557PubTator, text miningPubMed
42805992PubTator, text miningPubMed
42802076PubTator, text miningPubMed
42800308PubTator, text miningPubMed
42788731PubTator, text miningPubMed
42779767PubTator, text miningPubMed
42772652PubTator, text miningPubMed
42755578PubTator, text miningPubMed
42746390PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license