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PRNP: prion protein (Kanno blood group)

2 proteins, 292 patents, 0 drugs, 0 trials, 3,897 NIH grants and 13,239 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRNPHGNC
Nameprion protein (Kanno blood group)HGNC
NCBI Gene ID5621NCBI Gene
HGNC IDHGNC:9449HGNC
EnsemblENSG00000171867NCBI Gene
AliasesASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PRP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 2

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
F7VJQ1Alternative prion protein730GeneID, HGNCUniProt
P04156Major prion protein25370Ensembl, GeneID, HGNCUniProt

Patents 292

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-12291P04156Espacenet
US 12624354 B22026-05-12291P04156Espacenet
JP 2026062659 A2026-04-10291P04156Espacenet
US 12570972 B22026-03-10291P04156Espacenet
JP 2026004568 A2026-01-1459054P04156Espacenet
JP 2026004568 A2026-01-1459056P04156Espacenet
JP 2026000906 A2026-01-0630P04156Espacenet
US 12509680 B22025-12-30291P04156Espacenet
WO 2025264602 A12025-12-2662P04156Espacenet
EP 4650780 A22025-11-1910164P04156Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3897

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01AI077774Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases712,025NIH's project files
R01NS045585Role of microglial phagocytosis in prion diseases642,025NIH's project files
ZIAAI000580Structures and Activities of Prions and Prion Proteins472,025NIH's project files
ZIAAI001086Detection of Prions422,025NIH's project files
R01NS065244Mechanisms of Prion Protein Toxicity272,025NIH's project files
R01NS069566Mechanisms of Prion Aggregation262,025NIH's project files
R01AG034924mGluR5 and Phase State Dependent Synaptic Loss in Alzheimer's Disease242,025NIH's project files
ZIAAI000752Molecular Genetics Of Scrapie Pathogenesis192,025NIH's project files
ZIAAI000937Biology of Prion Protein and the TSE Diseases192,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions182,025NIH's project files

Papers 13239

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826842PubTator, text miningPubMed
42810629PubTator, text miningPubMed
42807189PubTator, text miningPubMed
42801967PubTator, text miningPubMed
42797788PubTator, text miningPubMed
42788215PubTator, text miningPubMed
42777650PubTator, text miningPubMed
42768708PubTator, text miningPubMed
42763563PubTator, text miningPubMed
42762716PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license