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PROC: protein C, inactivator of coagulation factors Va and VIIIa

1 protein, 149 patents, 2 drugs, 13 trials, 3,226 NIH grants and 15,233 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPROCHGNC
Nameprotein C, inactivator of coagulation factors Va and VIIIaHGNC
NCBI Gene ID5624NCBI Gene
HGNC IDHGNC:9451HGNC
EnsemblENSG00000115718NCBI Gene
AliasesAPC, PC, PROC1, THPH3, THPH4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04070Vitamin K-dependent protein C46112Ensembl, GeneID, HGNCUniProt

Patents 149

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19875P04070Espacenet
JP 2025169942 A2025-11-141244P04070Espacenet
JP 2025169942 A2025-11-141246P04070Espacenet
JP 2025147176 A2025-10-0610837P04070Espacenet
JP 2025529142 A2025-09-047437P04070Espacenet
US 12371689 B22025-07-297437P04070Espacenet
JP 2025517970 A2025-06-12875P04070Espacenet
JP 2025509184 A2025-04-11633P04070Espacenet
JP 2025509185 A2025-04-11241P04070Espacenet
JP 2025028160 A2025-02-2810837P04070Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PROTEIN C CONCENTRATE (HUMAN)CHEMBL5315087Vitamin K-dependent protein C exogenous proteinEXOGENOUS PROTEINChEMBL
PROTHROMBIN COMPLEX CONCENTRATECHEMBL6068614Vitamin K-dependent protein C exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 13

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07094087PROTHROMBIN COMPLEX CONCENTRATEPHASE3ClinicalTrials.gov
NCT05568888PROTHROMBIN COMPLEX CONCENTRATEPHASE32025-11-10ClinicalTrials.gov
NCT05523297PROTHROMBIN COMPLEX CONCENTRATEPHASE32025-08-15ClinicalTrials.gov
NCT04114643PROTHROMBIN COMPLEX CONCENTRATEPHASE2ClinicalTrials.gov
NCT03784794PROTHROMBIN COMPLEX CONCENTRATEClinicalTrials.gov
NCT03715348PROTHROMBIN COMPLEX CONCENTRATEPHASE2ClinicalTrials.gov
NCT03341156PROTHROMBIN COMPLEX CONCENTRATEPHASE3ClinicalTrials.gov
NCT02429453PROTHROMBIN COMPLEX CONCENTRATEClinicalTrials.gov
NCT02270918PROTHROMBIN COMPLEX CONCENTRATEPHASE1ClinicalTrials.gov
NCT01779921PROTHROMBIN COMPLEX CONCENTRATEClinicalTrials.gov

NIH grants 3226

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL049413Structural basis of prothrombin activation502,025NIH's project files
R01HL101917Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases282,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy282,025NIH's project files
R01HL142975Regulation of Protein C Pathways152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI112,025NIH's project files
R01HL139554Structural enzymology of protein C112,025NIH's project files
R01HL147821Structural enzymology of factor V activation102,025NIH's project files
T32HL007088Pre-and Postgraduate Training in Molecular Hematology82,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill82,025NIH's project files

Papers 15233

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42809655PubTator, text miningPubMed
42808109PubTator, text miningPubMed
42790483PubTator, text miningPubMed
42772339PubTator, text miningPubMed
42762956PubTator, text miningPubMed
42760619PubTator, text miningPubMed
42750175PubTator, text miningPubMed
42749602PubTator, text miningPubMed
42712784PubTator, text miningPubMed
42709574PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license