Gene · 5625
PRODH: proline dehydrogenase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PRODH: proline dehydrogenase 1. Genes, record 5625. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5625
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43272 | Proline dehydrogenase 1, mitochondrial | 600 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents18
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59182 | O43272 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7327 | O43272 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7327 | O43272 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34095 | O43272 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34099 | O43272 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 34095 | O43272 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 34099 | O43272 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 34095 | O43272 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 34099 | O43272 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 66909 | O43272 | Espacenet |
1 to 10 of 18
See all 18 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants861
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PRODH papers | Newest fiscal year |
|---|---|---|---|
| R01GM065546 | Substrate Channeling and Communication in Proline Metabolic Enzymes | 17 | 2025 |
| R01GM132640 | Investigating the Proline Cycle as a Potential Cancer Therapy Target | 11 | 2025 |
| UM1AI068614 | HIV Vaccines Clinical Trials Network Leadership and Operations Center | 7 | 2025 |
| P30GM124165 | NE-CAT: A Resource for Advanced Macromolecular Crystallography | 5 | 2025 |
| P30GM124169 | ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE) | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| UM1AI069453 | PHRU-Setshaba Clinical Trials Unit | 4 | 2025 |
| P30AI110527 | Tennessee Center for AIDS Research (TN-CFAR) | 3 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 3 | 2025 |
1 to 10 of 861Source NIH's project files
See all 861 nih grantsPapers1,468
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exogenous Polyamines and Plant Salinity Tolerance: A Systematic Review, Evidence Map, and Family-Aware Quantitative Synthesis. | Antioxidants (Basel) | 2026 | 42792204 | PubTator, text mining | PubMed |
| Proline Dehydrogenase Gene TaProDH1 Positively Regulates Wheat Resistance to Stripe Rust Disease. | J Fungi (Basel) | 2026 | 42783950 | PubTator, text mining | PubMed |
| Physiological Adaptation Strategy of the Pseudo-Metallophyte Lotus corniculatus L. to Long-Term Metal Contamination. | Antioxidants (Basel) | 2026 | 42650233 | PubTator, text mining | PubMed |
| Identification of a candidate PRODH allosteric inhibitor MBTP-15324: modulation of proline metabolite profiles and ECM-associated gene-expression changes in lung cancer cells. | J Enzyme Inhib Med Chem | 2026 | 42635425 | PubTator, text mining | PubMed |
| Investigation of the Effects of MT on the Antioxidant Capacity of Impatiens walleriana Under Water Deficit In Vitro. | Plants (Basel) | 2026 | 42514497 | PubTator, text mining | PubMed |
| Warming accelerates soil organic carbon mineralization in thawed seasonally frozen ground by reshaping carbon fractions. | Environ Monit Assess | 2026 | 42477191 | PubTator, text mining | PubMed |
| VK-2019 enhances gemcitabine's antitumor activity in EBV-positive nasopharyngeal carcinoma by upregulating PRODH expression. | Cell Death Discov | 2026 | 42420245 | PubTator, text mining | PubMed |
| Region-specific dysregulation of proline metabolic enzymes underlying mitochondrial dysfunction in the postmortem brains of patients with schizophrenia. | J Psychiatr Res | 2026 | 42365847 | PubTator, text mining | PubMed |
| Integrated biochemical, ionic and ultrastructural analysis of salinity tolerance in novel citrus rootstocks. | BMC Plant Biol | 2026 | 42210056 | PubTator, text mining | PubMed |
| Riboflavin-responsive hyperprolinemia type I with a PRODH p.Thr466Met variant: Clinical and fibroblast-based evidence. | Mol Genet Metab | 2026 | 42150437 | PubTator, text mining | PubMed |
1 to 10 of 1,468
See all 1,468 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5625
GET https://conductscience.org/api/genes/v1/5625/patents