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Gene · 5625

PRODH: proline dehydrogenase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRODH: proline dehydrogenase 1. Genes, record 5625. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5625

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Gene

Symbol
PRODH
HGNC
Name
proline dehydrogenase 1
HGNC
NCBI Gene ID
5625
NCBI Gene
HGNC ID
HGNC:9453
HGNC
Ensembl
ENSG00000100033
NCBI Gene
Aliases
HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43272Proline dehydrogenase 1, mitochondrial6000Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459182O43272Espacenet
EP 4641201 A22025-10-297327O43272Espacenet
JP 2025517969 A2025-06-127327O43272Espacenet
JP 2025032204 A2025-03-1134095O43272Espacenet
JP 2025032204 A2025-03-1134099O43272Espacenet
EP 4461818 A22024-11-1334095O43272Espacenet
EP 4461818 A22024-11-1334099O43272Espacenet
JP 2023058610 A2023-04-2534095O43272Espacenet
JP 2023058610 A2023-04-2534099O43272Espacenet
US 11446398 B22022-09-2066909O43272Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants861

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRODH papersNewest fiscal year
R01GM065546Substrate Channeling and Communication in Proline Metabolic Enzymes172025
R01GM132640Investigating the Proline Cycle as a Potential Cancer Therapy Target112025
UM1AI068614HIV Vaccines Clinical Trials Network Leadership and Operations Center72025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography52025
P30GM124169ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)52025
P30CA008748Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
UM1AI069453PHRU-Setshaba Clinical Trials Unit42025
P30AI110527Tennessee Center for AIDS Research (TN-CFAR)32025
P40OD010440Caenorhabditis Genetics Center32025

1 to 10 of 861Source NIH's project files

See all 861 nih grants

Papers1,468

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exogenous Polyamines and Plant Salinity Tolerance: A Systematic Review, Evidence Map, and Family-Aware Quantitative Synthesis.Antioxidants (Basel)202642792204PubTator, text miningPubMed
Proline Dehydrogenase Gene TaProDH1 Positively Regulates Wheat Resistance to Stripe Rust Disease.J Fungi (Basel)202642783950PubTator, text miningPubMed
Physiological Adaptation Strategy of the Pseudo-Metallophyte Lotus corniculatus L. to Long-Term Metal Contamination.Antioxidants (Basel)202642650233PubTator, text miningPubMed
Identification of a candidate PRODH allosteric inhibitor MBTP-15324: modulation of proline metabolite profiles and ECM-associated gene-expression changes in lung cancer cells.J Enzyme Inhib Med Chem202642635425PubTator, text miningPubMed
Investigation of the Effects of MT on the Antioxidant Capacity of Impatiens walleriana Under Water Deficit In Vitro.Plants (Basel)202642514497PubTator, text miningPubMed
Warming accelerates soil organic carbon mineralization in thawed seasonally frozen ground by reshaping carbon fractions.Environ Monit Assess202642477191PubTator, text miningPubMed
VK-2019 enhances gemcitabine's antitumor activity in EBV-positive nasopharyngeal carcinoma by upregulating PRODH expression.Cell Death Discov202642420245PubTator, text miningPubMed
Region-specific dysregulation of proline metabolic enzymes underlying mitochondrial dysfunction in the postmortem brains of patients with schizophrenia.J Psychiatr Res202642365847PubTator, text miningPubMed
Integrated biochemical, ionic and ultrastructural analysis of salinity tolerance in novel citrus rootstocks.BMC Plant Biol202642210056PubTator, text miningPubMed
Riboflavin-responsive hyperprolinemia type I with a PRODH p.Thr466Met variant: Clinical and fibroblast-based evidence.Mol Genet Metab202642150437PubTator, text miningPubMed

1 to 10 of 1,468

See all 1,468 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5625

GET https://conductscience.org/api/genes/v1/5625/patents