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Gene · 5629

PROX1: prospero homeobox 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PROX1: prospero homeobox 1. Genes, record 5629. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5629

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Gene

Symbol
PROX1
HGNC
Name
prospero homeobox 1
HGNC
NCBI Gene ID
5629
NCBI Gene
HGNC ID
HGNC:9459
HGNC
Ensembl
ENSG00000117707
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92786Prospero homeobox protein 17371Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459387Q92786Espacenet
JP 2026004568 A2026-01-1459389Q92786Espacenet
JP 2026004568 A2026-01-1459391Q92786Espacenet
EP 4641201 A22025-10-291483Q92786Espacenet
EP 4641201 A22025-10-298296Q92786Espacenet
JP 2025147176 A2025-10-0615539Q92786Espacenet
JP 2025121934 A2025-08-202Q92786Espacenet
JP 2025517969 A2025-06-121483Q92786Espacenet
JP 2025517969 A2025-06-128296Q92786Espacenet
JP 2025032204 A2025-03-1134101Q92786Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,651

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePROX1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)172025
P30CA008748Cancer Center Support Grant142025
UL1TR001863Yale Clinical and Translational Science Award132025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION92025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits92025
R01EY012200Pax6 as a key regulator of lens development92025
R01HL133216Molecular Mechanisms Controlling Lymphatic Vascular Function in Health and Disease82025
ZIAHG000024Genetic analysis of type II diabetes82025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72025
P30DK020572Michigan Diabetes Research Center (MDRC)72025

1 to 10 of 2,651Source NIH's project files

See all 2,651 nih grants

Papers3,195

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PROX1-associated lymphatic reprogramming signatures in pediatric adamantinomatous craniopharyngioma: a comparative study with adult cases.Front Pediatr202642819307PubTator, text miningPubMed
Genetically engineered porcine liver: a new era in transplantation.Int J Surg202642808109PubTator, text miningPubMed
Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Curr Issues Mol Biol202642793248PubTator, text miningPubMed
Ferroptosis, immune activation and MASH-related HCC.Gut202642722415PubTator, text miningPubMed
Engineering lymphatic collecting vessel phenotypes through combined hyaluronic acid cues and oscillatory shear stress.Cell Rep Methods202642697195PubTator, text miningPubMed
Prox1: A Novel Barrier to Retinal Regeneration and a Potential Target for Vision Restoration.WMJ202642623612PubTator, text miningPubMed
Restoration of oscillatory shear stress in humans activates an endothelial protective genetic program and prevents DVT.Blood202642611796PubTator, text miningPubMed
Impaired lymphatic drainage in a child with hydrops fetalis and a novel variant in the PROX1 gene: case report and review of literature.Front Cardiovasc Med202642591134PubTator, text miningPubMed
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs.Angiogenesis202642503070PubTator, text miningPubMed
The Scaffold Protein Liprin β-1 (PPFIBP1) and the Intermediate Filament Synemin: Potential New Markers of Lymphatic Endothelial Cells.Cells202642346091PubTator, text miningPubMed

1 to 10 of 3,195

See all 3,195 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5629

GET https://conductscience.org/api/genes/v1/5629/patents?page=2