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METTL3: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

1 protein, 19 patents, 0 drugs, 0 trials, 1,558 NIH grants and 7,139 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMETTL3HGNC
Namemethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunitHGNC
NCBI Gene ID56339NCBI Gene
HGNC IDHGNC:17563HGNC
EnsemblENSG00000165819NCBI Gene
AliasesIME4, M6A, MT-A70, Spo8, hMETTL3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q86U44N(6)-adenosine-methyltransferase catalytic subunit METTL358079Ensembl, GeneID, HGNCUniProt

Patents 19

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453408Q86U44Espacenet
EP 4650780 A22025-11-193888Q86U44Espacenet
WO 2025163107 A12025-08-075Q86U44Espacenet
JP 2025517970 A2025-06-123888Q86U44Espacenet
JP 2024515999 A2024-04-1176Q86U44Espacenet
US 11884978 B22024-01-30605Q86U44Espacenet
US 11753639 B22023-09-1266Q86U44Espacenet
US 11446398 B22022-09-2051108Q86U44Espacenet
JP 2022524081 A2022-04-27154079Q86U44Espacenet
JP 2021518841 A2021-08-0578Q86U44Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 1558

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal562,025NIH's project files
R01CA186702Mechanisms of epitranscriptomic regulation in cancer132,025NIH's project files
R35GM134744Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms122,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
R01CA271497The role and therapeutic potential of IGF2BP2 in MLL-rearranged leukemia112,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA92,025NIH's project files
R01AI125416Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection92,025NIH's project files
R35NS111631New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons92,025NIH's project files
R35ES031707Chemical Biology of DNA and RNA Alkylation82,025NIH's project files
R01HL136951Post-transcriptional regulation of cardiac hypertrophy72,025NIH's project files

Papers 7139

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823456PubTator, text miningPubMed
42818960PubTator, text miningPubMed
42818783PubTator, text miningPubMed
42817804PubTator, text miningPubMed
42804733PubTator, text miningPubMed
42798441PubTator, text miningPubMed
42793095PubTator, text miningPubMed
42780040PubTator, text miningPubMed
42777928PubTator, text miningPubMed
42776380PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license