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Gene · 5641

LGMN: legumain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LGMN: legumain. Genes, record 5641. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5641

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Gene

Symbol
LGMN
HGNC
Name
legumain
HGNC
NCBI Gene ID
5641
NCBI Gene
HGNC ID
HGNC:9472
HGNC
Ensembl
ENSG00000100600
NCBI Gene
Aliases
AEP, LGMN1, PRSC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99538Legumain43318Ensembl, GeneID, HGNC

Source UniProt

Patents83

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451230Q99538Espacenet
JP 2026004568 A2026-01-1451231Q99538Espacenet
EP 4650780 A22025-11-196072Q99538Espacenet
EP 4641201 A22025-10-295803Q99538Espacenet
JP 2025534299 A2025-10-1544Q99538Espacenet
JP 2025147176 A2025-10-067840Q99538Espacenet
JP 2025147176 A2025-10-067841Q99538Espacenet
JP 2025529142 A2025-09-046888Q99538Espacenet
US 12371689 B22025-07-296888Q99538Espacenet
JP 2025517969 A2025-06-125803Q99538Espacenet

1 to 10 of 83

See all 83 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,066

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLGMN papersNewest fiscal year
UL1TR002378Georgia Clinical & Translational Science Alliance (Georgia CTSA)142025
T32CA009302Leveraging innovative technologies in basic and clinical cancer research52025
P30AG066511Goizueta Alzheimer's Disease Research Center42025
P30CA062203Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant32025
P30CA072720Cancer Center Support Grant32025
R01NS102722Endosomal Platforms for Signaling Pain32025
R35GM149272Next-generation optical nanoprobes: From quantum biosensing to cellular monitoring32025
ZIAAI000810Vector-Borne Diseases: Biology Of Vector Host Relationship32025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses22025

1 to 10 of 1,066Source NIH's project files

See all 1,066 nih grants

Papers1,807

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Double-Edged Sword: Legumain as a Context-Dependent Mediator and Therapeutic Target in Cancer and Cardiovascular Disease.Cells202642782778PubTator, text miningPubMed
Granzyme B PET Imaging Reveals Lgmn+ Macrophage-Mediated Immune Evasion and Guides Immunotherapy in EGFR-TKI-Resistant NSCLC.Adv Sci (Weinh)202642750201PubTator, text miningPubMed
The Oral-Brain Axis: A Unified Framework Linking Trigeminal Sensorimotor Dysfunction, Chronic Stress, Neuroinflammation, and Neurodegeneration.Int J Mol Sci202642737498PubTator, text miningPubMed
Spatiotemporal Sequential Fluorescence and Electrochemistry Bimodal Quantitation of Enzyme Activity in a Living Cell.Nano Lett202642715043PubTator, text miningPubMed
Synergistic Regulation of Alzheimer's Disease and Intestinal Microbiota Metabolism Mediated by the Gut-Brain Axis: A Comprehensive Analysis from a Multidisciplinary Perspective.Int J Med Sci202642694564PubTator, text miningPubMed
Exosome-Associated Proteins as Mediators and Biomarkers of Ovarian Cancer Dissemination.Biomolecules202642650816PubTator, text miningPubMed
Protease-Mediated TAR DNA-Binding Protein 43 (TDP-43) Pathogenesis: From Molecular Mechanisms to Therapeutic Opportunities.ACS Pharmacol Transl Sci202642614660PubTator, text miningPubMed
LGMN regulates endothelial-to-mesenchymal transition via the p38 MAPK pathway to promote pulmonary fibrosis.Funct Integr Genomics202642527573PubTator, text miningPubMed
Crosstalk in Alzheimer's-delirium nexus: Molecular mechanisms and therapeutic repurposing.Int Rev Neurobiol202642442909PubTator, text miningPubMed
Mapping tissue-specific protease dynamics in the pig respiratory tract during influenza a virus infection.Sci Rep202642414375PubTator, text miningPubMed

1 to 10 of 1,807

See all 1,807 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5641

GET https://conductscience.org/api/genes/v1/5641/patents?page=2