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Gene · 5644

PRSS1: serine protease 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRSS1: serine protease 1. Genes, record 5644. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5644

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Gene

Symbol
PRSS1
HGNC
Name
serine protease 1
HGNC
NCBI Gene ID
5644
NCBI Gene
HGNC ID
HGNC:9475
HGNC
Ensembl
ENSG00000204983
NCBI Gene
Aliases
TRP1, TRY1, TRY4, TRYP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07477Serine protease 124712Ensembl, GeneID, HGNC

Source UniProt

Patents68

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459438P07477Espacenet
EP 4650780 A22025-11-194573P07477Espacenet
EP 4641201 A22025-10-294130P07477Espacenet
JP 2025147176 A2025-10-0610884P07477Espacenet
JP 2025529142 A2025-09-047448P07477Espacenet
US 12371689 B22025-07-297448P07477Espacenet
JP 2025517969 A2025-06-124130P07477Espacenet
JP 2025517970 A2025-06-124573P07477Espacenet
JP 2025028160 A2025-02-2810884P07477Espacenet
KR 1020250010750 A2025-01-2110884P07477Espacenet

1 to 10 of 68

See all 68 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,188

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRSS1 papersNewest fiscal year
U01DK108334INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies332025
U01DK108306UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes222025
P30DK054759Precision Medicine Center for Cystic Fibrosis212025
P30CA006973Regional Oncology Research Center162025
P30CA008748Cancer Center Support Grant152025
P30CA016672Cancer Center Support Grant142025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease92025
U01DK108314Cedars Sinai Center for the Chronic Pancreatitis Clinical Research Consortium82025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant72025
P30CA086862Cancer Center Support Grant72025

1 to 10 of 1,188Source NIH's project files

See all 1,188 nih grants

Papers2,344

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Patients With Pancreatitis-Related Gene Variants Showed Higher Incidence of Hyperpancreatic Enzymemia After Endoscopic Retrograde Cholangiopancreatography.DEN Open202742058267PubTator, text miningPubMed
Multilevel genome-wide analysis reveals shared genetic architecture between acute pancreatitis and body fat distribution.World J Emerg Med202642807309PubTator, text miningPubMed
De novo PRSS1 p.Asn29Ile Mutation Causing Hereditary Pancreatitis in an Indian Child.Ann Afr Med202642745203PubTator, text miningPubMed
PRSS1 isoforms promote type 2 immune responses in IgG4-related disease.Genes Immun202642731986PubTator, text miningPubMed
Exploring the therapeutic potential of Astragalin in Parkinson's disease: a network pharmacology approach.Ann Med Surg (Lond)202642724825PubTator, text miningPubMed
A First-Trimester Serum Proteomic Signature for Early Prediction of Preeclampsia: Integrated Untargeted and Targeted Mass Spectrometry with Machine Learning.Life (Basel)202642652952PubTator, text miningPubMed
PRSS1 promotes gastric cancer invasion and metastasis by induction of the epithelial-mesenchymal transition and activation of the MAPK/ERK pathway.Transl Cancer Res202642591552PubTator, text miningPubMed
PRSS1A16V germline mutation is common in a cohort of intraductal papillary mucinous neoplasms of the pancreas.Surgery202642561641PubTator, text miningPubMed
Early-Onset and Rapidly Progressive Hereditary Pancreatitis Associated with PRSS1 Mutations in a Romanian Pediatric Cohort.Maedica (Bucur)202642416742PubTator, text miningPubMed
NHE7-Driven endoplasmic reticulum stress signaling transmission promotes malignant progression of endometrial cancer via c-Fos/PRSS1/ERP27 axis.J Exp Clin Cancer Res202642387646PubTator, text miningPubMed

1 to 10 of 2,344

See all 2,344 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5644

GET https://conductscience.org/api/genes/v1/5644/patents?page=2