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Gene · 5648

MASP1: MBL associated serine protease 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MASP1: MBL associated serine protease 1. Genes, record 5648. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5648

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Gene

Symbol
MASP1
HGNC
Name
MBL associated serine protease 1
HGNC
NCBI Gene ID
5648
NCBI Gene
HGNC ID
HGNC:6901
HGNC
Ensembl
ENSG00000127241
NCBI Gene
Aliases
3MC1, CRARF, CRARF1, MAP-1, MAP1, MASP, MASP-3, MASP3, MAp44, Map44, PRSS5, RaRF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48740Mannan-binding lectin serine protease 16999Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452507P48740Espacenet
EP 4650780 A22025-11-196224P48740Espacenet
JP 2025147176 A2025-10-068323P48740Espacenet
JP 2025529142 A2025-09-046978P48740Espacenet
US 12371689 B22025-07-296978P48740Espacenet
WO 2025132452 A12025-06-2611P48740Espacenet
JP 2025517970 A2025-06-126224P48740Espacenet
JP 2025032204 A2025-03-1131233P48740Espacenet
JP 2025028160 A2025-02-288323P48740Espacenet
KR 1020250010750 A2025-01-218323P48740Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants897

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMASP1 papersNewest fiscal year
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis142025
R01DK078244Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
I01RX000444Complement Factor H-based Therapeutic Strategies in Macular Degeneration32025
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies32025
R01DK110023C3 Glomerulopathy -- A Collaborative Study32025
P30CA016672Cancer Center Support Grant22025
P30CA034196Cancer Center Support (CORE) Grant22025
P30CA086862Cancer Center Support Grant22025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT22025

1 to 10 of 897Source NIH's project files

See all 897 nih grants

Papers2,041

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells.Front Immunol202642746023PubTator, text miningPubMed
Traumatic Brain Injury in the Omics Era: Plasma and Extracellular Vesicle Proteomic Signatures in Polytrauma.Med Sci (Basel)202642646564PubTator, text miningPubMed
Point-of-care assessment of complement activation in the ICU: a feasibility study of rapid terminal complement complex detection in critical illness.Front Immunol202642643423PubTator, text miningPubMed
Sex-Associated Proteomic Signatures Persist Independent of Injury Severity and Shock Physiology in Acute Trauma.Shock202642625553PubTator, text miningPubMed
Diverging Liquid-Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins.Adv Sci (Weinh)202642621696PubTator, text miningPubMed
Coordinated suppression of lectin complement pathway effectors and upregulation of SERPING1 defines a thrombo-inflammatory regulatory signature in Acute Coronary disease.Mol Biol Rep202642606632PubTator, text miningPubMed
Serum complement system activation in normal healing and atrophic non-union of human long bone fractures.Front Immunol202642344890PubTator, text miningPubMed
Screening and identification of key genes related to the immune microenvironment of rectal cancer influenced by radiotherapy based on bioinformatics methods.Discov Oncol202642298234PubTator, text miningPubMed
Prenatal Phenotype of Common Arterial Trunk With Tricuspid Atresia and Bilateral Cleft Lip-Palate With Novel MASP1 Variant.Prenat Diagn202642185514PubTator, text miningPubMed
Correlation of serum MAp44 protein concentration with degree of myocardial injury and 30-day prognosis in patients with acute myocardial infarction.Am J Transl Res202642170458PubTator, text miningPubMed

1 to 10 of 2,041

See all 2,041 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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