ConductScience.org, home

Gene · 5649

RELN: reelin

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. RELN: reelin. Genes, record 5649. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5649

On this page

Gene

Symbol
RELN
HGNC
Name
reelin
HGNC
NCBI Gene ID
5649
NCBI Gene
HGNC ID
HGNC:9957
HGNC
Ensembl
ENSG00000189056
NCBI Gene
Aliases
ETL7, LIS2, PRO1598, RL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78509Reelin3,4601Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1912516P78509Espacenet
EP 4641201 A22025-10-2913759P78509Espacenet
JP 2025147176 A2025-10-0611314P78509Espacenet
JP 2025529142 A2025-09-047547P78509Espacenet
US 12371689 B22025-07-297547P78509Espacenet
JP 2025517969 A2025-06-1213759P78509Espacenet
JP 2025517970 A2025-06-1212516P78509Espacenet
JP 2025032204 A2025-03-1134717P78509Espacenet
JP 2025028160 A2025-02-2811314P78509Espacenet
KR 1020250010750 A2025-01-2111314P78509Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants3,176

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRELN papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)142025
P30CA008748Cancer Center Support Grant112025
UL1TR001863Yale Clinical and Translational Science Award112025
P30CA016672Cancer Center Support Grant82025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)82025
R01NS058721ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders72025
R01NS081297The Development and Integration of Early Born SST-Expressing Interneurons in the Cortex52025
R24HD000836Laboratory of Developmental Biology52025
R35GM128915Molecular Principles Governing Mitochondrial and Peroxisomal Remodeling as Drivers of Cell Fate and Identity52025
R37NS035129Human Epilepsy Genetics - Mosaic Mutations in Focal Epilepsy52025

1 to 10 of 3,176Source NIH's project files

See all 3,176 nih grants

Papers3,990

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Zygosity-Dependent Phenotypic Spectrum of RELN-Related Disorders: 10 New Patients and Genotype-Phenotype Correlations Across 48 Kindreds.Hum Mutat202642761500PubTator, text miningPubMed
Integrative analysis of single-cell multi-omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease.Clin Transl Med202642728785PubTator, text miningPubMed
Lymphatics-epicardial cross talk via Reelin controls cardiac growth.Genes Dev202642728022PubTator, text miningPubMed
The neuronal network of small cell lung cancer: a narrative review of the role of the nervous system in the pathogenesis and progression.Transl Lung Cancer Res202642723782PubTator, text miningPubMed
High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer's disease.PLoS Comput Biol202642640981PubTator, text miningPubMed
Functional Reelin signaling deficits without interneuron loss are associated with neuroblast misplacement after non-convulsive status epilepticus.Neurobiol Dis202642637105PubTator, text miningPubMed
Alzheimer's Disease DNA Methylation Index (AD-DMI) and its Association with Late-Life Cognitive Function.NPJ Dement202642583477PubTator, text miningPubMed
Molecular links between reelin downregulation, topoisomerase IIβ alterations, and proteins involved in Alzheimer pathology in human SH-SY5Y neuroblastoma cell line.Exp Brain Res202642377581PubTator, text miningPubMed
Broader autism phenotype, the default mode network, and brain entropy: A network-level hypothesis.Res Neurodivers202642369596PubTator, text miningPubMed
The association study of genetic variants with developing musical aptitude in humans.Vavilovskii Zhurnal Genet Selektsii202642245177PubTator, text miningPubMed

1 to 10 of 3,990

See all 3,990 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5649

GET https://conductscience.org/api/genes/v1/5649/patents?page=2