Gene · 5654
HTRA1: HtrA serine peptidase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HTRA1: HtrA serine peptidase 1. Genes, record 5654. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5654
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92743 | Serine protease HTRA1 | 480 | 18 | Ensembl, GeneID, HGNC |
Source UniProt
Patents86
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 188 | Q92743 | Espacenet |
| US 12570741 B2 | 2026-03-10 | 28 | Q92743 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49417 | Q92743 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 177 | Q92743 | Espacenet |
| JP 2025175283 A | 2025-12-01 | 4 | Q92743 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8540 | Q92743 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6630 | Q92743 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 177 | Q92743 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6626 | Q92743 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6626 | Q92743 | Espacenet |
1 to 10 of 86
See all 86 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,906
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HTRA1 papers | Newest fiscal year |
|---|---|---|---|
| P30EY014800 | University of Utah Core Vision Research Grant | 32 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 15 | 2025 |
| ZIAEY000489 | Age-Related Eye Disease Follow-up Study (AREDS) Follow-up Study | 15 | 2025 |
| ZIAEY000546 | Mechanisms, modeling and therapies of retinal and macular neurodegeneration | 15 | 2025 |
| P30EY014801 | Miami Center for Vision Research | 11 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 10 | 2025 |
| P30EY001583 | P30 Core Grant For Vision Research | 9 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 8 | 2025 |
| R01EY022445 | Use of Correlated Data Methods in Ophthalmology | 7 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 6 | 2025 |
1 to 10 of 1,906Source NIH's project files
See all 1,906 nih grantsPapers3,290
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| HTRA1 and RGS3 as Candidate Genes Associated with Shared Stromal-Immune Dysregulation across Atherosclerotic Plaques and Premature Ovarian Insufficiency. | Curr Med Chem | 2026 | 42816985 | PubTator, text mining | PubMed |
| Exploring causal associations between the plasma proteome and bone mineral density: a Mendelian randomization study. | Endocr Connect | 2026 | 42765911 | PubTator, text mining | PubMed |
| Artificial intelligence for precision therapeutics in age-related macular degeneration: current advances, challenges, and future directions. | Front Artif Intell | 2026 | 42676384 | PubTator, text mining | PubMed |
| Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease. | Clin Genet | 2026 | 42661427 | PubTator, text mining | PubMed |
| Plexiform Wagner-Meissner schwannoma with a SH3PXD2A::HTRA1 fusion: a twisted sister? | Histopathology | 2026 | 42644309 | PubTator, text mining | PubMed |
| Single-Cell Proteomics Uncovers Cell-Specific Proteins in Vascular Health and Marfan Syndrome Disease-Brief Report. | Arterioscler Thromb Vasc Biol | 2026 | 42592649 | PubTator, text mining | PubMed |
| The perfusion-based model of AMD: Moving towards a unifying hypothesis. | Prog Retin Eye Res | 2026 | 42556705 | PubTator, text mining | PubMed |
| Host and Helicobacter pylori HtrA protease variants converge on Wnt/β-catenin signaling to drive stomach adenocarcinoma. | Gut Microbes | 2026 | 42493827 | PubTator, text mining | PubMed |
| Whole-exome sequencing identifies matrisomal gene associations in monogenic cerebral small vessel disease. | J Neurol | 2026 | 42481886 | PubTator, text mining | PubMed |
| The vascular contribution to dementia: World Stroke Organization scientific statement. | Int J Stroke | 2026 | 42454751 | PubTator, text mining | PubMed |
1 to 10 of 3,290
See all 3,290 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5654
GET https://conductscience.org/api/genes/v1/5654/patents?page=2