ConductScience.org, home

Gene · 5654

HTRA1: HtrA serine peptidase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HTRA1: HtrA serine peptidase 1. Genes, record 5654. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5654

On this page

Gene

Symbol
HTRA1
HGNC
Name
HtrA serine peptidase 1
HGNC
NCBI Gene ID
5654
NCBI Gene
HGNC ID
HGNC:9476
HGNC
Ensembl
ENSG00000166033
NCBI Gene
Aliases
ARMD7, CADASIL2, CARASIL, CARASIL2, HtrA, IGFBP5-protease, L56, ORF480, PRSS11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92743Serine protease HTRA148018Ensembl, GeneID, HGNC

Source UniProt

Patents86

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19188Q92743Espacenet
US 12570741 B22026-03-1028Q92743Espacenet
JP 2026004568 A2026-01-1449417Q92743Espacenet
EP 4667578 A22025-12-24177Q92743Espacenet
JP 2025175283 A2025-12-014Q92743Espacenet
EP 4650780 A22025-11-198540Q92743Espacenet
JP 2025147176 A2025-10-066630Q92743Espacenet
JP 2025131621 A2025-09-09177Q92743Espacenet
JP 2025529142 A2025-09-046626Q92743Espacenet
US 12371689 B22025-07-296626Q92743Espacenet

1 to 10 of 86

See all 86 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,906

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTRA1 papersNewest fiscal year
P30EY014800University of Utah Core Vision Research Grant322025
P30EY005722Center Core Grant for Vision Research152025
ZIAEY000489Age-Related Eye Disease Follow-up Study (AREDS) Follow-up Study152025
ZIAEY000546Mechanisms, modeling and therapies of retinal and macular neurodegeneration152025
P30EY014801Miami Center for Vision Research112025
P30DK058404Molecular and Cellular Basis for Digestive Diseases102025
P30EY001583P30 Core Grant For Vision Research92025
P30EY014104P30 Core Grant for Vision Research82025
R01EY022445Use of Correlated Data Methods in Ophthalmology72025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer62025

1 to 10 of 1,906Source NIH's project files

See all 1,906 nih grants

Papers3,290

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HTRA1 and RGS3 as Candidate Genes Associated with Shared Stromal-Immune Dysregulation across Atherosclerotic Plaques and Premature Ovarian Insufficiency.Curr Med Chem202642816985PubTator, text miningPubMed
Exploring causal associations between the plasma proteome and bone mineral density: a Mendelian randomization study.Endocr Connect202642765911PubTator, text miningPubMed
Artificial intelligence for precision therapeutics in age-related macular degeneration: current advances, challenges, and future directions.Front Artif Intell202642676384PubTator, text miningPubMed
Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease.Clin Genet202642661427PubTator, text miningPubMed
Plexiform Wagner-Meissner schwannoma with a SH3PXD2A::HTRA1 fusion: a twisted sister?Histopathology202642644309PubTator, text miningPubMed
Single-Cell Proteomics Uncovers Cell-Specific Proteins in Vascular Health and Marfan Syndrome Disease-Brief Report.Arterioscler Thromb Vasc Biol202642592649PubTator, text miningPubMed
The perfusion-based model of AMD: Moving towards a unifying hypothesis.Prog Retin Eye Res202642556705PubTator, text miningPubMed
Host and Helicobacter pylori HtrA protease variants converge on Wnt/β-catenin signaling to drive stomach adenocarcinoma.Gut Microbes202642493827PubTator, text miningPubMed
Whole-exome sequencing identifies matrisomal gene associations in monogenic cerebral small vessel disease.J Neurol202642481886PubTator, text miningPubMed
The vascular contribution to dementia: World Stroke Organization scientific statement.Int J Stroke202642454751PubTator, text miningPubMed

1 to 10 of 3,290

See all 3,290 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5654

GET https://conductscience.org/api/genes/v1/5654/patents?page=2