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PSEN2: presenilin 2

1 protein, 95 patents, 7 drugs, 67 trials, 3,620 NIH grants and 6,552 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPSEN2HGNC
Namepresenilin 2HGNC
NCBI Gene ID5664NCBI Gene
HGNC IDHGNC:9509HGNC
EnsemblENSG00000143801NCBI Gene
AliasesAD3L, AD4, CMD1V, E5-1, PS-2, PS2, STM2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P49810Presenilin-24482Ensembl, GeneID, HGNCUniProt

Patents 95

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459032P49810Espacenet
EP 4650780 A22025-11-198111P49810Espacenet
JP 2025529142 A2025-09-043601P49810Espacenet
JP 2025527208 A2025-08-20166P49810Espacenet
US 12371689 B22025-07-293601P49810Espacenet
JP 2025517970 A2025-06-128111P49810Espacenet
JP 2025062601 A2025-04-143P49810Espacenet
US 11958898 B22024-04-16104P49810Espacenet
US 11919967 B22024-03-053P49810Espacenet
JP 2023179538 A2023-12-192P49810Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVAGACESTATCHEMBL1090771Gamma-secretase inhibitorINHIBITORChEMBL
BEGACESTATCHEMBL463981Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTATCHEMBL1770916Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTAT HYDROBROMIDECHEMBL4298153Gamma-secretase inhibitorINHIBITORChEMBL
RG-4733CHEMBL4297422Gamma-secretase inhibitorINHIBITORChEMBL
SEMAGACESTATCHEMBL520733Gamma-secretase inhibitorINHIBITORChEMBL
TARENFLURBILCHEMBL190083Gamma-secretase modulatorMODULATORChEMBL

Trials 67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07539454NIROGACESTATPHASE2ClinicalTrials.gov
NCT07176689NIROGACESTATPHASE4ClinicalTrials.gov
NCT07170644NIROGACESTATPHASE2ClinicalTrials.gov
NCT07150104NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07150091NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07084896NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05949099NIROGACESTATPHASE2ClinicalTrials.gov
NCT05879146NIROGACESTATPHASE2ClinicalTrials.gov
NCT05573802NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05556798NIROGACESTATPHASE1ClinicalTrials.gov

NIH grants 3620

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)1202,025NIH's project files
U19AG032438Bridge Funding for Dominantly Inherited Alzheimer Network1112,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study722,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions452,025NIH's project files
P30AG066444Alzheimer's Disease Research Center322,025NIH's project files
P30AG066509University of Washington Alzheimer's Disease Research Center182,025NIH's project files
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)182,025NIH's project files
P30AG062422New Approaches to Dementia Heterogeneity172,025NIH's project files
UL1TR002345Washington University Institute of Clinical and Translational Sciences162,025NIH's project files
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)152,025NIH's project files

Papers 6552

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821203PubTator, text miningPubMed
42819414PubTator, text miningPubMed
42779813PubTator, text miningPubMed
42751194PubTator, text miningPubMed
42744164PubTator, text miningPubMed
42712639PubTator, text miningPubMed
42653368PubTator, text miningPubMed
42650158PubTator, text miningPubMed
42634522PubTator, text miningPubMed
42593621PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license