Gene · 56655
POLE4: DNA polymerase epsilon 4, accessory subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. POLE4: DNA polymerase epsilon 4, accessory subunit. Genes, record 56655. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56655
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NR33 | DNA polymerase epsilon subunit 4 | 117 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58476 | Q9NR33 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 14409 | Q9NR33 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 14409 | Q9NR33 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 65016 | Q9NR33 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 167987 | Q9NR33 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8705 | Q9NR33 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 719 | Q9NR33 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 238911 | Q9NR33 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 238911 | Q9NR33 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 238911 | Q9NR33 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants921
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | POLE4 papers | Newest fiscal year |
|---|---|---|---|
| P01CA100730 | Retrovirus Models of Cancer | 18 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| ZIABC005645 | Role of the HTLV-1A and HTLV1-C inflammatory profile in disease | 12 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| ZIANS002817 | Involvement Of Human Viruses Associated With Chronic Neurologic Disease | 5 | 2025 |
| P20GM103427 | Nebraska Research Network in Functional Genomics | 4 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 4 | 2025 |
| R01AI052014 | HIV-1 Preintegration Trafficking and Nuclear Localization | 4 | 2025 |
| ZIANS003040 | Translational studies of human viruses and chronic neurologic disease | 4 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 921Source NIH's project files
See all 921 nih grantsPapers1,638
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cryo-EM structures of human caspase-4 in complex with full-length gasdermin D. | Structure | 2026 | 42442362 | PubTator, text mining | PubMed |
| Structural basis for RISC assembly of human Argonaute2. | Mol Cell | 2026 | 42190652 | PubTator, text mining | PubMed |
| Virus-like and Virus Replicon Particles Targeting Multiple B-Cell Antigens Do Not Protect Against African Swine Fever Virus. | Vaccines (Basel) | 2026 | 41893821 | PubTator, text mining | PubMed |
| Functional Characterization of POLE1 Variant Fibroblasts Reveals Replication Stress and Increased Sensitivity to Genotoxic Stress. | Diseases | 2026 | 41891994 | PubTator, text mining | PubMed |
| HTLV-1 genetic diversity of 52 complete sequences from 14 African countries reveals novel variants and a lack of typical P12/P8 and P30 accessory proteins in HTLV-1b, d, and f genotypes. | Emerg Microbes Infect | 2026 | 41879736 | PubTator, text mining | PubMed |
| Signal peptidase complex mediates rotavirus VP7 processing and virion assembly. | PLoS Pathog | 2026 | 41860932 | PubTator, text mining | PubMed |
| A bioinformatics and experimental study toward new therapeutic strategies: CXCL8 in gout progression. | Medicine (Baltimore) | 2026 | 41790703 | PubTator, text mining | PubMed |
| Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor. | Purinergic Signal | 2026 | 41776109 | PubTator, text mining | PubMed |
| Vaccination with an African Swine Fever Virus Multiepitope Protein Chitosan Nanoparticle-Based Subunit Vaccine Elicits Robust Immune Responses In Vivo. | Vaccines (Basel) | 2026 | 41746107 | PubTator, text mining | PubMed |
| Epidemiology and Clinical Outcomes of HTLV-1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions. | Can J Infect Dis Med Microbiol | 2026 | 41737026 | PubTator, text mining | PubMed |
1 to 10 of 1,638
See all 1,638 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/56655
GET https://conductscience.org/api/genes/v1/56655/patents?page=2