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Gene · 56655

POLE4: DNA polymerase epsilon 4, accessory subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLE4: DNA polymerase epsilon 4, accessory subunit. Genes, record 56655. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56655

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Gene

Symbol
POLE4
HGNC
Name
DNA polymerase epsilon 4, accessory subunit
HGNC
NCBI Gene ID
56655
NCBI Gene
HGNC ID
HGNC:18755
HGNC
Ensembl
ENSG00000115350
NCBI Gene
Aliases
YHHQ1, p12
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NR33DNA polymerase epsilon subunit 41170Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458476Q9NR33Espacenet
EP 4650780 A22025-11-1914409Q9NR33Espacenet
JP 2025517970 A2025-06-1214409Q9NR33Espacenet
US 11446398 B22022-09-2065016Q9NR33Espacenet
JP 2022524081 A2022-04-27167987Q9NR33Espacenet
US 11078247 B22021-08-038705Q9NR33Espacenet
WO 2020043864 A12020-03-05719Q9NR33Espacenet
JP 2019054813 A2019-04-11238911Q9NR33Espacenet
JP 2017121241 A2017-07-13238911Q9NR33Espacenet
JP 2015516143 A2015-06-08238911Q9NR33Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants921

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLE4 papersNewest fiscal year
P01CA100730Retrovirus Models of Cancer182025
P30CA016672Cancer Center Support Grant122025
ZIABC005645Role of the HTLV-1A and HTLV1-C inflammatory profile in disease122025
P30CA016058Cancer Center Support Grant52025
ZIANS002817Involvement Of Human Viruses Associated With Chronic Neurologic Disease52025
P20GM103427Nebraska Research Network in Functional Genomics42025
P30CA036727Buffett Cancer Center Support Grant42025
R01AI052014HIV-1 Preintegration Trafficking and Nuclear Localization42025
ZIANS003040Translational studies of human viruses and chronic neurologic disease42025
P30CA013696Cancer Center Support Grant32025

1 to 10 of 921Source NIH's project files

See all 921 nih grants

Papers1,638

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cryo-EM structures of human caspase-4 in complex with full-length gasdermin D.Structure202642442362PubTator, text miningPubMed
Structural basis for RISC assembly of human Argonaute2.Mol Cell202642190652PubTator, text miningPubMed
Virus-like and Virus Replicon Particles Targeting Multiple B-Cell Antigens Do Not Protect Against African Swine Fever Virus.Vaccines (Basel)202641893821PubTator, text miningPubMed
Functional Characterization of POLE1 Variant Fibroblasts Reveals Replication Stress and Increased Sensitivity to Genotoxic Stress.Diseases202641891994PubTator, text miningPubMed
HTLV-1 genetic diversity of 52 complete sequences from 14 African countries reveals novel variants and a lack of typical P12/P8 and P30 accessory proteins in HTLV-1b, d, and f genotypes.Emerg Microbes Infect202641879736PubTator, text miningPubMed
Signal peptidase complex mediates rotavirus VP7 processing and virion assembly.PLoS Pathog202641860932PubTator, text miningPubMed
A bioinformatics and experimental study toward new therapeutic strategies: CXCL8 in gout progression.Medicine (Baltimore)202641790703PubTator, text miningPubMed
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor.Purinergic Signal202641776109PubTator, text miningPubMed
Vaccination with an African Swine Fever Virus Multiepitope Protein Chitosan Nanoparticle-Based Subunit Vaccine Elicits Robust Immune Responses In Vivo.Vaccines (Basel)202641746107PubTator, text miningPubMed
Epidemiology and Clinical Outcomes of HTLV-1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions.Can J Infect Dis Med Microbiol202641737026PubTator, text miningPubMed

1 to 10 of 1,638

See all 1,638 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/56655

GET https://conductscience.org/api/genes/v1/56655/patents?page=2