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Gene · 5682

PSMA1: proteasome 20S subunit alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMA1: proteasome 20S subunit alpha 1. Genes, record 5682. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5682

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Gene

Symbol
PSMA1
HGNC
Name
proteasome 20S subunit alpha 1
HGNC
NCBI Gene ID
5682
NCBI Gene
HGNC ID
HGNC:9530
HGNC
Ensembl
ENSG00000129084
NCBI Gene
Aliases
HC2, HEL-S-275, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25786Proteasome subunit alpha type-1263177Ensembl, GeneID, HGNC

Source UniProt

Patents85

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459499P25786Espacenet
JP 2026004568 A2026-01-1459500P25786Espacenet
EP 4650780 A22025-11-1911387P25786Espacenet
JP 2025517970 A2025-06-1211387P25786Espacenet
US 11860162 B22024-01-021142P25786Espacenet
JP 2023106701 A2023-08-024P25786Espacenet
US 11694765 B22023-07-04282P25786Espacenet
US 11474104 B22022-10-189P25786Espacenet
US 11446398 B22022-09-2067847P25786Espacenet
JP 2022524081 A2022-04-27170818P25786Espacenet

1 to 10 of 85

See all 85 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants754

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMA1 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control72025
ZIAAI000904Staphylococcal pathogenesis72025
P30CA008748Cancer Center Support Grant32025
ZICES102445Gene Expression and Microarrays32025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA015704Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30CA047904Cancer Center Support Grant22025
P30CA225520Stephenson Cancer Center - Cancer Center Support Grant22025

1 to 10 of 754Source NIH's project files

See all 754 nih grants

Papers901

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PSMA1, PSMA5, and PSMB2 serve as prognostic biomarkers and are correlated with tumor-infiltrating leukocytes in HCC.Epigenetics202642735232PubTator, text miningPubMed
Commentary: Tumor associated neutrophils promote prostate cancer progression by mediating neutrophil trap secretion through PSMA1- NF-κB-HIF-1α signaling axis.Front Immunol202642723983PubTator, text miningPubMed
In Vivo Multimodal Self-Immolative Prodrug Nanomicelle-Hydrogel Modulate Key Intratumoral and Metastatic Genomic Signaling Pathways in Pancreatic Cancer.ACS Nano Med202642639086PubTator, text miningPubMed
CircUBE2I regulates YAP/TAZ signaling pathway through miR-659-3p/PSMA1 axis to promote human lung adenocarcinoma cell progression.Exp Cell Res202642612899PubTator, text miningPubMed
Integrated proteomics and machine learning for identifying candidate serum biomarkers in acute myocardial infarction-complicated cardiogenic shock: a prospective exploratory study.Clin Proteomics202642477545PubTator, text miningPubMed
Integrative analysis of the PSMA family identifies PSMA6 as an adverse prognostic biomarker promoting bladder cancer cell proliferation.Int J Med Sci202641799753PubTator, text miningPubMed
Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First-Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model.MedComm (2020)202641782964PubTator, text miningPubMed
Multi-platform integration of brain and CSF proteomes reveals biomarker panels for Alzheimer's disease.Brief Bioinform202641608987PubTator, text miningPubMed
LDOC1 connects histone H2B monoubiquitination to tumor cell plasticity in non-small cell lung cancer.Cell Commun Signal202641484780PubTator, text miningPubMed
[Protein biomarker screening and functional analysis of salivary exosomes in patients with ulcerative colitis].Beijing Da Xue Xue Bao Yi Xue Ban202541131760PubTator, text miningPubMed

1 to 10 of 901

See all 901 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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