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Gene · 5683

PSMA2: proteasome 20S subunit alpha 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMA2: proteasome 20S subunit alpha 2. Genes, record 5683. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5683

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Gene

Symbol
PSMA2
HGNC
Name
proteasome 20S subunit alpha 2
HGNC
NCBI Gene ID
5683
NCBI Gene
HGNC ID
HGNC:9531
HGNC
Ensembl
ENSG00000106588
NCBI Gene
Aliases
HC3, MU, PMSA2, PSC2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25787Proteasome subunit alpha type-2234177Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459503P25787Espacenet
EP 4650780 A22025-11-19594P25787Espacenet
JP 2025517970 A2025-06-12594P25787Espacenet
JP 2024009871 A2024-01-2315P25787Espacenet
US 11446398 B22022-09-2067852P25787Espacenet
US 11446398 B22022-09-2075660P25787Espacenet
JP 2022524081 A2022-04-27170823P25787Espacenet
JP 2022524081 A2022-04-27178631P25787Espacenet
KR 1020210152990 A2021-12-165P25787Espacenet
KR 1020210111195 A2021-09-105P25787Espacenet

1 to 10 of 41

See all 41 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants539

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMA2 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control82025
ZIAAI000904Staphylococcal pathogenesis62025
P30CA016058Cancer Center Support Grant32025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P50CA168504Dana Farber/Harvard Cancer Center Specialized Program of Research Excellence in Breast Cancer22025
P50CA186781Mayo Clinic Multiple Myeloma SPORE22025
K08AI151265Functions for novel IL-15-responsive macrophages in the uterus during pregnancy12025
K12EY022299Michigan Vision Clinician Scientist Development Program12025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study12025

1 to 10 of 539Source NIH's project files

See all 539 nih grants

Papers707

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery of hub genes linking oxidative stress to type 2 diabetic sarcopenia using single-cell sequencing and machine learning.PLoS One202642412755PubTator, text miningPubMed
Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts.Cell Rep202642276069PubTator, text miningPubMed
Analysis of core target genes of vagus nerve stimulation in epilepsy, ischemic stroke, and depression: Separate insights from network pharmacology, bioinformatics, and Mendelian randomization.Medicine (Baltimore)202642071808PubTator, text miningPubMed
Integrative analysis of the PSMA family identifies PSMA6 as an adverse prognostic biomarker promoting bladder cancer cell proliferation.Int J Med Sci202641799753PubTator, text miningPubMed
Identification of multigene predictors of prognosis in patients with ovarian cancer.iScience202641767263PubTator, text miningPubMed
Takotsubo Syndrome: The First Non-Acute Proteomic Analysis by Remote Dried Blood Microsampling.J Cardiovasc Transl Res202641760974PubTator, text miningPubMed
Circulating Cell Type Senescence Signatures Reveal High-Resolution Health Status and Trajectories in Human Longitudinal Studies.medRxiv202641728302PubTator, text miningPubMed
PRRSV Nsp12 targets PSMA2 to suppress host proteasome activity and promote viral survival.Vet Microbiol202641475191PubTator, text miningPubMed
Prognostic Value and Immune Characterization of Genes Associated with Childhood Acute Leukemia applying Single-Cell RNA Sequencing.Endocr Metab Immune Disord Drug Targets202640910197PubTator, text miningPubMed
METTL14 Regulates the Expression of Genes Related to Interferon, Interleukin and MHC Class I in Nasopharyngeal Carcinoma Cells.Cancer Med202541316520PubTator, text miningPubMed

1 to 10 of 707

See all 707 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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