Gene · 56848
SPHK2: sphingosine kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SPHK2: sphingosine kinase 2. Genes, record 56848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56848
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NRA0 | Sphingosine kinase 2 | 654 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents47
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 127 | Q9NRA0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 812 | Q9NRA0 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 127 | Q9NRA0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 812 | Q9NRA0 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36398 | Q9NRA0 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36401 | Q9NRA0 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36398 | Q9NRA0 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36401 | Q9NRA0 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8524 | Q9NRA0 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8529 | Q9NRA0 | Espacenet |
1 to 10 of 47
See all 47 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ABC-294640 | CHEMBL2158685 | Sphingosine kinase 2 inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04502069 | ABC-294640 | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04467840 | ABC-294640 | PHASE2/PHASE3 | 2023-10-19 | ClinicalTrials.gov |
| NCT04435106 | ABC-294640 | ClinicalTrials.gov | ||
| NCT04414618 | ABC-294640 | PHASE2 | 2022-03-21 | ClinicalTrials.gov |
| NCT04207255 | ABC-294640 | PHASE2 | 2024-09-25 | ClinicalTrials.gov |
| NCT03414489 | ABC-294640 | ClinicalTrials.gov | ||
| NCT03377179 | ABC-294640 | PHASE2 | ClinicalTrials.gov | |
| NCT02939807 | ABC-294640 | PHASE2 | ClinicalTrials.gov | |
| NCT02757326 | ABC-294640 | PHASE1/PHASE2 | 2021-06-18 | ClinicalTrials.gov |
| NCT02229981 | ABC-294640 | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants1,129
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SPHK2 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 36 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 25 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 15 | 2025 |
| R01DE016572 | Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy | 11 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 8 | 2025 |
| R35GM118128 | Neutral Sphingomyelinases and Bioactive Ceramides | 7 | 2025 |
| T32HL007829 | Training Program in Lung Biology and Pathobiology | 7 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 6 | 2025 |
| IK6BX004477 | BLR&D Research Career Scientist Award Application | 5 | 2025 |
| U54GM104940 | Louisiana Clinical and Translational Science Center | 5 | 2025 |
1 to 10 of 1,129Source NIH's project files
See all 1,129 nih grantsPapers2,132
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Sphingosine 1-phosphate signalling contributes to transforming growth factor-β1-induced myofibroblast differentiation in oral cancer. | PeerJ | 2026 | 42730290 | PubTator, text mining | PubMed |
| DHCR24 regulates endothelial senescence through the SPHK2/SPNS2-S1P axis. | Biogerontology | 2026 | 42704384 | PubTator, text mining | PubMed |
| Stereoselective access to allenic sphingosine analogues as SphK inhibitors. | Org Biomol Chem | 2026 | 42605829 | PubTator, text mining | PubMed |
| Li C, Wu B, Li Y, et al. Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness. Blood. 2022;140(15):1686-1701. | Blood | 2026 | 42593798 | PubTator, text mining | PubMed |
| Genome-wide methylation profiling identifies signatures of pain, fatigue and health scores in women with systemic lupus erythematosus. | Rheumatology (Oxford) | 2026 | 42530360 | PubTator, text mining | PubMed |
| Lipid-driven epigenetic exhaustion: linking palmitate metabolism to CD8+ T-cell dysfunction in cancer. | Immunometabolism (Cobham) | 2026 | 42487663 | PubTator, text mining | PubMed |
| CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection. | J Immunol | 2026 | 42433041 | PubTator, text mining | PubMed |
| Bidirectional mendelian randomization identifies plasma proteins associated with cervical cancer risk. | J Egypt Natl Canc Inst | 2026 | 42384160 | PubTator, text mining | PubMed |
| Brain-Derived Proteins Induce Autoimmune Responses via MBP-IgG Immune Complexes and Participate in Pulmonary Edema Following Traumatic Brain Injury. | J Neurotrauma | 2026 | 42300019 | PubTator, text mining | PubMed |
| Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke. | Fluids Barriers CNS | 2026 | 42277837 | PubTator, text mining | PubMed |
1 to 10 of 2,132
See all 2,132 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/56848
GET https://conductscience.org/api/genes/v1/56848/patents?page=2