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Gene · 56848

SPHK2: sphingosine kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPHK2: sphingosine kinase 2. Genes, record 56848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56848

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Gene

Symbol
SPHK2
HGNC
Name
sphingosine kinase 2
HGNC
NCBI Gene ID
56848
NCBI Gene
HGNC ID
HGNC:18859
HGNC
Ensembl
ENSG00000063176
NCBI Gene
Aliases
SK 2, SK-2, SPK 2, SPK-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NRA0Sphingosine kinase 26540Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-29127Q9NRA0Espacenet
EP 4641201 A22025-10-29812Q9NRA0Espacenet
JP 2025519096 A2025-06-24127Q9NRA0Espacenet
JP 2025517969 A2025-06-12812Q9NRA0Espacenet
JP 2025032204 A2025-03-1136398Q9NRA0Espacenet
JP 2025032204 A2025-03-1136401Q9NRA0Espacenet
EP 4461818 A22024-11-1336398Q9NRA0Espacenet
EP 4461818 A22024-11-1336401Q9NRA0Espacenet
JP 2024123008 A2024-09-108524Q9NRA0Espacenet
JP 2024123008 A2024-09-108529Q9NRA0Espacenet

1 to 10 of 47

See all 47 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ABC-294640CHEMBL2158685Sphingosine kinase 2 inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04502069ABC-294640PHASE1/PHASE2ClinicalTrials.gov
NCT04467840ABC-294640PHASE2/PHASE32023-10-19ClinicalTrials.gov
NCT04435106ABC-294640ClinicalTrials.gov
NCT04414618ABC-294640PHASE22022-03-21ClinicalTrials.gov
NCT04207255ABC-294640PHASE22024-09-25ClinicalTrials.gov
NCT03414489ABC-294640ClinicalTrials.gov
NCT03377179ABC-294640PHASE2ClinicalTrials.gov
NCT02939807ABC-294640PHASE2ClinicalTrials.gov
NCT02757326ABC-294640PHASE1/PHASE22021-06-18ClinicalTrials.gov
NCT02229981ABC-294640PHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,129

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPHK2 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy362025
P30CA016059Massey Cancer Center - Cancer Center Support Grant252025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant152025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy112025
P30CA016056Roswell Park Cancer Center Support Grant82025
R35GM118128Neutral Sphingomyelinases and Bioactive Ceramides72025
T32HL007829Training Program in Lung Biology and Pathobiology72025
P30CA044579University of Virginia Cancer Center Support Grant62025
IK6BX004477BLR&D Research Career Scientist Award Application52025
U54GM104940Louisiana Clinical and Translational Science Center52025

1 to 10 of 1,129Source NIH's project files

See all 1,129 nih grants

Papers2,132

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Sphingosine 1-phosphate signalling contributes to transforming growth factor-β1-induced myofibroblast differentiation in oral cancer.PeerJ202642730290PubTator, text miningPubMed
DHCR24 regulates endothelial senescence through the SPHK2/SPNS2-S1P axis.Biogerontology202642704384PubTator, text miningPubMed
Stereoselective access to allenic sphingosine analogues as SphK inhibitors.Org Biomol Chem202642605829PubTator, text miningPubMed
Li C, Wu B, Li Y, et al. Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness. Blood. 2022;140(15):1686-1701.Blood202642593798PubTator, text miningPubMed
Genome-wide methylation profiling identifies signatures of pain, fatigue and health scores in women with systemic lupus erythematosus.Rheumatology (Oxford)202642530360PubTator, text miningPubMed
Lipid-driven epigenetic exhaustion: linking palmitate metabolism to CD8+ T-cell dysfunction in cancer.Immunometabolism (Cobham)202642487663PubTator, text miningPubMed
CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection.J Immunol202642433041PubTator, text miningPubMed
Bidirectional mendelian randomization identifies plasma proteins associated with cervical cancer risk.J Egypt Natl Canc Inst202642384160PubTator, text miningPubMed
Brain-Derived Proteins Induce Autoimmune Responses via MBP-IgG Immune Complexes and Participate in Pulmonary Edema Following Traumatic Brain Injury.J Neurotrauma202642300019PubTator, text miningPubMed
Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke.Fluids Barriers CNS202642277837PubTator, text miningPubMed

1 to 10 of 2,132

See all 2,132 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/56848

GET https://conductscience.org/api/genes/v1/56848/patents?page=2