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Gene · 5685

PSMA4: proteasome 20S subunit alpha 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMA4: proteasome 20S subunit alpha 4. Genes, record 5685. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5685

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Gene

Symbol
PSMA4
HGNC
Name
proteasome 20S subunit alpha 4
HGNC
NCBI Gene ID
5685
NCBI Gene
HGNC ID
HGNC:9533
HGNC
Ensembl
ENSG00000041357
NCBI Gene
Aliases
HC9, HsT17706, PSC9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25789Proteasome subunit alpha type-4261177Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459507P25789Espacenet
JP 2026004568 A2026-01-1459509P25789Espacenet
EP 4650780 A22025-11-1977P25789Espacenet
JP 2025517970 A2025-06-1277P25789Espacenet
WO 2024240908 A12024-11-2827P25789Espacenet
US 11446398 B22022-09-2067863P25789Espacenet
US 11446398 B22022-09-2067875P25789Espacenet
JP 2022524081 A2022-04-27170834P25789Espacenet
JP 2022524081 A2022-04-27170846P25789Espacenet
US 11078247 B22021-08-039059P25789Espacenet

1 to 10 of 41

See all 41 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants902

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMA4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control72025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).52025
P30CA008748Cancer Center Support Grant42025
P30CA022453CANCER CENTER SUPPORT GRANT42025
R35CA197449Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research32025
ZIAAI000904Staphylococcal pathogenesis32025
P30CA015704Cancer Center Support Grant22025
P30CA016520Abramson Cancer Center Support Grant22025
P30CA076292Moffitt Cancer Center Support Grant22025

1 to 10 of 902Source NIH's project files

See all 902 nih grants

Papers825

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.FASEB J202642698337PubTator, text miningPubMed
From locus to gene: causal inference and experimental validation prioritize PSMA4 as a candidate target in lung adenocarcinoma.Am J Cancer Res202642163891PubTator, text miningPubMed
Identification of PSMA4 as a Therapeutic Target for Atherosclerosis: A Comprehensive Multiomics Mendelian Randomization Analysis.Ann Hum Genet202642032825PubTator, text miningPubMed
A comparative analysis of serum and tissue proteomic profiles in non-small cell lung cancer patients with or without brain metastasis.Cell Death Discov202641974650PubTator, text miningPubMed
Integrating genome-wide association studies with quantitative trait loci prioritised PSMA4 as a risk gene for pneumonia.ERJ Open Res202641953759PubTator, text miningPubMed
Exploring the shared genetic architecture between periodontitis and cardiovascular disease.BDJ Open202641916952PubTator, text miningPubMed
Machine learning and single-cell RNA sequencing analyses identify MS-related monocytes and a five-gene candidate biomarker signature.Front Neurol202641756175PubTator, text miningPubMed
Proteomic Insights into Venous Thromboembolism.Med Sci (Basel)202641718141PubTator, text miningPubMed
PSMA4 as a Druggable Target in Hidradenitis Suppurativa: Evidence From Mendelian Randomization and Single-Cell Transcriptomics.Mediators Inflamm202641685341PubTator, text miningPubMed
Identifying Therapeutic Targets for Bronchial Asthma: Systematic Druggable Genome-Wide Mendelian Randomization.Health Sci Rep202641573111PubTator, text miningPubMed

1 to 10 of 825

See all 825 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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