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Gene · 56852

RAD18: RAD18 E3 ubiquitin protein ligase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAD18: RAD18 E3 ubiquitin protein ligase. Genes, record 56852. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56852

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Gene

Symbol
RAD18
HGNC
Name
RAD18 E3 ubiquitin protein ligase
HGNC
NCBI Gene ID
56852
NCBI Gene
HGNC ID
HGNC:18278
HGNC
Ensembl
ENSG00000070950
NCBI Gene
Aliases
RNF73
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NS91E3 ubiquitin-protein ligase RAD184958Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192414Q9NS91Espacenet
EP 4641201 A22025-10-291993Q9NS91Espacenet
JP 2025517969 A2025-06-121993Q9NS91Espacenet
JP 2025517970 A2025-06-122414Q9NS91Espacenet
EP 4524569 A22025-03-1930Q9NS91Espacenet
JP 2024123008 A2024-09-107999Q9NS91Espacenet
US 12023339 B22024-07-0230Q9NS91Espacenet
US 11976334 B22024-05-07191Q9NS91Espacenet
US 11591295 B22023-02-2830Q9NS91Espacenet
US 11446398 B22022-09-2071037Q9NS91Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants943

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAD18 papersNewest fiscal year
P30ES010126UNC Center for Environmental Health and Susceptibility212025
P30CA016672Cancer Center Support Grant102025
P30CA016086Cancer Center Support Grant82025
P01CA092584Structural Cell Biology of DNA Repair Machines72025
R01ES016486Regulation of the DNA Damage Response72025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants62025
R01CA248526Mechanisms of replication fork protection and recovery62025
R01ES026184The Role of Mono-ADP-Ribosylation by PARP14 in Radioresistance62025
R01GM134681The role of DNA damage tolerance pathways in human cells62025
ZIAHD001500DNA Replication, Repair, and Mutagenesis In Eukaryotic And Prokaryotic Cells62025

1 to 10 of 943Source NIH's project files

See all 943 nih grants

Papers1,350

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A novel mechanism of ubiquitin-charging a bivalent E2:RING E3 complex.bioRxiv202642818655PubTator, text miningPubMed
Overlapping RAD18-and DNA-binding interfaces in DNA polymerase η contribute to UV-induced DNA damage tolerance.J Biol Chem202642744252PubTator, text miningPubMed
Progress for RAD18's mechanism in breast cancer radioresistant.Open Life Sci202642713304PubTator, text miningPubMed
The Oligomeric State of Rad6-Rad18 and Its Interactions with Translesion Synthesis Proteins.Biomolecules202642650838PubTator, text miningPubMed
Neuroinflammation- molecular target based therapeutic approach.Adv Protein Chem Struct Biol202642448410PubTator, text miningPubMed
The miR-221-5p/RAD18/RAD51 Axis Regulates DNA Damage Tolerance and Homologous Recombination to Drive Platinum Resistance in Ovarian Cancer.bioRxiv202642182447PubTator, text miningPubMed
USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality.bioRxiv202642146504PubTator, text miningPubMed
Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR.Genes Dev202642140672PubTator, text miningPubMed
RAD18 facilitates cancer progression and immunosuppression via the AKT/mTOR/c-Myc axis: a multi-omics analysis.NPJ Precis Oncol202642115304PubTator, text miningPubMed
Novel HBx-interacting host cellular factors regulate dynamic nuclear and cytoplasmic localization of Hepatitis B virus X protein (HBx).Virology202642105427PubTator, text miningPubMed

1 to 10 of 1,350

See all 1,350 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/56852

GET https://conductscience.org/api/genes/v1/56852/patents?page=2