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Gene · 5686

PSMA5: proteasome 20S subunit alpha 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMA5: proteasome 20S subunit alpha 5. Genes, record 5686. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5686

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Gene

Symbol
PSMA5
HGNC
Name
proteasome 20S subunit alpha 5
HGNC
NCBI Gene ID
5686
NCBI Gene
HGNC ID
HGNC:9534
HGNC
Ensembl
ENSG00000143106
NCBI Gene
Aliases
PSC5, ZETA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28066Proteasome subunit alpha type-5241177Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459514P28066Espacenet
EP 4650780 A22025-11-192766P28066Espacenet
JP 2025517970 A2025-06-122766P28066Espacenet
WO 2024240908 A12024-11-2828P28066Espacenet
US 11446398 B22022-09-2067876P28066Espacenet
JP 2022524081 A2022-04-27170847P28066Espacenet
EP 3647788 A12020-05-0621P28066Espacenet
WO 2020043864 A12020-03-051953P28066Espacenet
KR 1020200020927 A2020-02-2621P28066Espacenet
JP 2019054813 A2019-04-11239949P28066Espacenet

1 to 10 of 21

See all 21 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants555

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMA5 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control72025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30CA016520Abramson Cancer Center Support Grant22025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant22025
ZICES102445Gene Expression and Microarrays22025
K12EY022299Michigan Vision Clinician Scientist Development Program12025
P01CA092584Structural Cell Biology of DNA Repair Machines12025
P01CA229086The impact of changes in chromatin architecture on cancer phenotypes and tumor progression12025
P20GM103475Advancing Competitive Biomedical Research in Puerto Rico12025

1 to 10 of 555Source NIH's project files

See all 555 nih grants

Papers689

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PSMA1, PSMA5, and PSMB2 serve as prognostic biomarkers and are correlated with tumor-infiltrating leukocytes in HCC.Epigenetics202642735232PubTator, text miningPubMed
Exosomal gene-based predictive model and therapeutic target identification for Alzheimer's disease: A bioinformatics analysis.PLoS One202642475384PubTator, text miningPubMed
Sarcomatoid Renal Cell Carcinoma: Biological Features and Therapeutic Implications-A Narrative Review.Curr Urol Rep202641792526PubTator, text miningPubMed
Ubiquitin-proteasome system dysregulation in FAM111B-related poikiloderma and phenotypic spectrum expansion: new case reports and long-term follow-up.EBioMedicine202540840166PubTator, text miningPubMed
Development and validation of G2M signature-based prognostic model for stratifying colon cancer prognosis.Discov Oncol202540783878PubTator, text miningPubMed
PSMA5 as a modulator of glioblastoma senescence and prognosis.BMC Cancer202540597008PubTator, text miningPubMed
Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease.J Alzheimers Dis202540111921PubTator, text miningPubMed
Are cities under bright lights more innovative? Evidence from China.Heliyon202439253158PubTator, text miningPubMed
Unveiling the role of PSMA5 in glioma progression and prognosis.Discov Oncol202439240463PubTator, text miningPubMed
Role and mechanism of IRF9 in promoting the progression of rheumatoid arthritis by regulating macrophage polarization via PSMA5.Heliyon202439170377PubTator, text miningPubMed

1 to 10 of 689

See all 689 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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