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Gene · 5687

PSMA6: proteasome 20S subunit alpha 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMA6: proteasome 20S subunit alpha 6. Genes, record 5687. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5687

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Gene

Symbol
PSMA6
HGNC
Name
proteasome 20S subunit alpha 6
HGNC
NCBI Gene ID
5687
NCBI Gene
HGNC ID
HGNC:9535
HGNC
Ensembl
ENSG00000100902
NCBI Gene
Aliases
IOTA, MGC22756, MGC2333, MGC23846, PROS27, p27K
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P60900Proteasome subunit alpha type-6246176Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459516P60900Espacenet
EP 4650780 A22025-11-191900P60900Espacenet
JP 2025517970 A2025-06-121900P60900Espacenet
JP 2024009871 A2024-01-2382P60900Espacenet
US 11446398 B22022-09-2067878P60900Espacenet
JP 2022524081 A2022-04-27170849P60900Espacenet
JP 2021521876 A2021-08-3096P60900Espacenet
WO 2019211343 A12019-11-0782P60900Espacenet
JP 2019054813 A2019-04-11239951P60900Espacenet
EP 3403091 A12018-11-21685P60900Espacenet

1 to 10 of 37

See all 37 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants610

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMA6 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
P30CA015704Cancer Center Support Grant42025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30CA076292Moffitt Cancer Center Support Grant22025
P30DK063491Diabetes Research Center (DRC)22025
P50CA186781Mayo Clinic Multiple Myeloma SPORE22025

1 to 10 of 610Source NIH's project files

See all 610 nih grants

Papers729

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PSMA6 drives non-small cell lung cancer progression by stabilizing NEDD8 and activating NF-κB signaling.Transl Lung Cancer Res202642723894PubTator, text miningPubMed
Identification of PANoptosis-related biomarkers in spinal cord injury (SCI) through multi-omics analysis and machine learning.Int J Neurosci202642037113PubTator, text miningPubMed
Integrative analysis of the PSMA family identifies PSMA6 as an adverse prognostic biomarker promoting bladder cancer cell proliferation.Int J Med Sci202641799753PubTator, text miningPubMed
Identification of causally linked blood biomarkers for Alzheimer's disease via reverse transcriptome-wide Mendelian randomization.J Alzheimers Dis202641789865PubTator, text miningPubMed
A new digenic inheritance of proteasome-associated autoinflammatory syndrome involving the PSMA6 gene.J Allergy Clin Immunol Pract202641205671PubTator, text miningPubMed
Zinc-Related Proteasome Variants in Type 1 Diabetes: An in Silico-Guided Case-Control Study.Metabolites202541441015PubTator, text miningPubMed
Enhanced microbiological evaluation of brain abscesses by proteomics-based techniques: a prospective cohort study.Neurosurg Focus202541175401PubTator, text miningPubMed
Reverse control of biological networks to restore phenotype landscapes.Sci Adv202540845098PubTator, text miningPubMed
Target discovery-directed pharmacological mechanism elucidation of bioactive natural products.Med Rev (2021)202540838108PubTator, text miningPubMed
Comparative Analysis of the Tumour Mutational Burden in Erosive and Reticular Oral Lichen Planus.Oral Dis202540616231PubTator, text miningPubMed

1 to 10 of 729

See all 729 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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