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Gene · 5689

PSMB1: proteasome 20S subunit beta 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMB1: proteasome 20S subunit beta 1. Genes, record 5689. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5689

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Gene

Symbol
PSMB1
HGNC
Name
proteasome 20S subunit beta 1
HGNC
NCBI Gene ID
5689
NCBI Gene
HGNC ID
HGNC:9537
HGNC
Ensembl
ENSG00000008018
NCBI Gene
Aliases
HC5, NEDMHAL, PMSB1, PSC5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20618Proteasome subunit beta type-1241176Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459527P20618Espacenet
EP 4650780 A22025-11-192031P20618Espacenet
JP 2025517970 A2025-06-122031P20618Espacenet
WO 2024240908 A12024-11-286P20618Espacenet
US 11446398 B22022-09-2067900P20618Espacenet
JP 2022524081 A2022-04-27170871P20618Espacenet
US 11078247 B22021-08-039063P20618Espacenet
JP 2019054813 A2019-04-11239962P20618Espacenet
JP 2017121241 A2017-07-13239962P20618Espacenet
JP 2015516143 A2015-06-08239962P20618Espacenet

1 to 10 of 18

See all 18 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants651

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMB1 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
ZIAAI000904Staphylococcal pathogenesis52025
ZIAAI001080Role of the human microbiota and probiotics32025
P01AI169768High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir22025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes22025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30AI060354Harvard University Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P30CA016086Cancer Center Support Grant22025

1 to 10 of 651Source NIH's project files

See all 651 nih grants

Papers738

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-Cell-Derived Malignant Epithelial Programs Define Prognostic Risk and Therapeutic Vulnerability in Ovarian Cancer.J Cancer202642524312PubTator, text miningPubMed
PSMB1 screened by CRISPR-CAS9 promoted breast cancer progression via PI3K-AKT-mTOR signaling.Discov Oncol202642177737PubTator, text miningPubMed
5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis.EBioMedicine202641861514PubTator, text miningPubMed
Identifying prioritization of potential targets for idiopathic pulmonary fibrosis: Proteome-wide Mendelian randomization and colocalization analyses.Clinics (Sao Paulo)202641855608PubTator, text miningPubMed
Autophagy regulation and viral exploitation: insights into African swine fever virus pathogenesis.Front Cell Infect Microbiol202641778015PubTator, text miningPubMed
Multi-omics SMR and experimental supportive analyses decipher causal drivers hepatocellular carcinoma.BMC Cancer202641699549PubTator, text miningPubMed
Proteomics Reveals Differential Diagnosis Biomarkers Between Sepsis and Hemophagocytic Syndrome.Biomedicines202541463121PubTator, text miningPubMed
Clinical characteristics and whole-genome analysis of methicillin-resistant Staphylococcus aureus in ICU patients from a tertiary hospital in southern China.Int J Med Microbiol202541289896PubTator, text miningPubMed
Enhanced microbiological evaluation of brain abscesses by proteomics-based techniques: a prospective cohort study.Neurosurg Focus202541175401PubTator, text miningPubMed
Prediction of Immunotherapy Response and Prognostic Outcomes for Patients With Ovarian Cancer Using PANoptosis-Related Genes.Hum Mutat202541141246PubTator, text miningPubMed

1 to 10 of 738

See all 738 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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