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Gene · 5690

PSMB2: proteasome 20S subunit beta 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMB2: proteasome 20S subunit beta 2. Genes, record 5690. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5690

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Gene

Symbol
PSMB2
HGNC
Name
proteasome 20S subunit beta 2
HGNC
NCBI Gene ID
5690
NCBI Gene
HGNC ID
HGNC:9539
HGNC
Ensembl
ENSG00000126067
NCBI Gene
Aliases
HC7-I
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49721Proteasome subunit beta type-2201154Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459531P49721Espacenet
EP 4650780 A22025-11-199278P49721Espacenet
JP 2025517970 A2025-06-129278P49721Espacenet
JP 2023509848 A2023-03-1086P49721Espacenet
JP 2023509849 A2023-03-1086P49721Espacenet
US 11446398 B22022-09-2067903P49721Espacenet
JP 2022524081 A2022-04-27170874P49721Espacenet
JP 2019054813 A2019-04-11239966P49721Espacenet
JP 2017121241 A2017-07-13239966P49721Espacenet
US 9696323 B22017-07-0414P49721Espacenet

1 to 10 of 37

See all 37 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants715

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMB2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant42025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control42025
UL1TR002345Washington University Institute of Clinical and Translational Sciences42025
ZIAAI000904Staphylococcal pathogenesis42025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
R01GM131641Mapping endogenous protein dynamics in living cells32025
UL1TR001863Yale Clinical and Translational Science Award32025
P01AI169768High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir22025
P01CA092584Structural Cell Biology of DNA Repair Machines22025

1 to 10 of 715Source NIH's project files

See all 715 nih grants

Papers733

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PSMA1, PSMA5, and PSMB2 serve as prognostic biomarkers and are correlated with tumor-infiltrating leukocytes in HCC.Epigenetics202642735232PubTator, text miningPubMed
Integrative systems biology identifies PSMB2 as a core oxidative stress-associated target in triple-negative breast cancer.Naunyn Schmiedebergs Arch Pharmacol202642624926PubTator, text miningPubMed
Targeting PSMB2 suppresses glioblastoma progression and sensitizes tumors to temozolomide by modulating PTEN/PI3K/AKT pathway.Gene202642476328PubTator, text miningPubMed
Multi-omic profiling converges on proteasome subunits PSMA7/PSMB2 as targets of the sepsis-protective agent Handelin.Front Immunol202641939900PubTator, text miningPubMed
Identification of multigene predictors of prognosis in patients with ovarian cancer.iScience202641767263PubTator, text miningPubMed
Extracellular Vesicles in Migraine: Biomarkers and Therapeutics.Mol Neurobiol202641708555PubTator, text miningPubMed
Integration analysis of single-cell and spatial transcriptomics identifies prognostic genes associated with neddylation in colorectal cancer.Discov Oncol202541444773PubTator, text miningPubMed
METTL14 Regulates the Expression of Genes Related to Interferon, Interleukin and MHC Class I in Nasopharyngeal Carcinoma Cells.Cancer Med202541316520PubTator, text miningPubMed
SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating.J Virol202541288382PubTator, text miningPubMed
In silico biological discovery with large perturbation models.Nat Comput Sci202541094040PubTator, text miningPubMed

1 to 10 of 733

See all 733 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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