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Gene · 56901

COXFA4L2: cytochrome c oxidase hypoxia associated subunit FA4L2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COXFA4L2: cytochrome c oxidase hypoxia associated subunit FA4L2. Genes, record 56901. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56901

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Gene

Symbol
COXFA4L2
HGNC
Name
cytochrome c oxidase hypoxia associated subunit FA4L2
HGNC
NCBI Gene ID
56901
NCBI Gene
HGNC ID
HGNC:29836
HGNC
Ensembl
ENSG00000185633
NCBI Gene
Aliases
FLJ26118, MISTRH, NDUFA4L2, NUOMS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NRX3Cytochrome c oxidase hypoxia associated subunit FA4L2870Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911073Q9NRX3Espacenet
JP 2025529142 A2025-09-042806Q9NRX3Espacenet
US 12371689 B22025-07-292806Q9NRX3Espacenet
JP 2025517970 A2025-06-1211073Q9NRX3Espacenet
JP 2025024198 A2025-02-1913919Q9NRX3Espacenet
JP 2025024198 A2025-02-1913920Q9NRX3Espacenet
US 11446398 B22022-09-2055060Q9NRX3Espacenet
US 11446398 B22022-09-2055061Q9NRX3Espacenet
JP 2022524081 A2022-04-27158031Q9NRX3Espacenet
JP 2022524081 A2022-04-27158032Q9NRX3Espacenet

1 to 10 of 22

See all 22 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants262

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOXFA4L2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant22025
P30CA014520UW Comprehensive Cancer Center Support22025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant22025
P30ES019776HERCULES: Exposome Research Center22025
P30MH092177Comprehensive NeuroHIV Center22025
R35GM118141Mitochondrial Biogenesis in Health and Disease22025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.12025
I01BX002930HDAC7-driven metabolic remodeling in renal tumor progression12025
K00CA253718Deciphering molecular mechanisms of Epithelial Plasticity12025
K08HL163398Molecular regulation of cell fate and progenitor function in the distal human respiratory airways12025

1 to 10 of 262Source NIH's project files

See all 262 nih grants

Papers416

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Multi-Gene Myofibroblast Framework Stratifies Prognostic and Immune Landscapes in HCC.Curr Gene Ther202642393881PubTator, text miningPubMed
BRG1-mediated suppression of ferroptosis underlies BTK inhibitor resistance.Nat Commun202642393054PubTator, text miningPubMed
NDUFA4L2 acts as a mitochondrial checkpoint against ferroptosis in hypoxic clear cell renal cell carcinoma.Cell Signal202642331208PubTator, text miningPubMed
YY1/HIF-1α/NDUFA4L2 signaling axis mediates bisphenol A-induced mitochondrial dysfunction and apoptosis in human ovarian granulosa cells.Reprod Toxicol202642322997PubTator, text miningPubMed
Epigenetics of Genes Displaying High and Preferential Expression in Myoblasts.Epigenomes202641892369PubTator, text miningPubMed
A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer.Z Gastroenterol202641862194PubTator, text miningPubMed
Targeting regulated cell death pathways in lung cancer: mechanisms, therapeutic strategies, and clinical translation.Front Immunol202641789093PubTator, text miningPubMed
NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis.NPJ Precis Oncol202641787028PubTator, text miningPubMed
Cornus officinalis Fruit Extract as an AMPK-Associated Mitochondrial Bioenergetic Modulator in Skin Aging Models.Biomedicines202641751302PubTator, text miningPubMed
Bioinformatics Analysis of Genes Associated with Autophagy and Metabolic Reprogramming in Atrial Fibrillation.J Cardiovasc Dev Dis202641745330PubTator, text miningPubMed

1 to 10 of 416

See all 416 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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